Serum cystatin C predicts vancomycin trough levels better than serum creatinine in hospitalized patients: a cohort study

Table 2 Univariate predictors of vancomycin trough level, mg/L

Potential baseline predictor	Beta	P value
Demographic and anthropometric data
Age, year	0.057	0.06
Male	−0.076	0.97
Height, cm	−0.015	0.72
Weight, kg	0.039	0.12
Kidney function markers
Log creatinine, mg/dL	5.320	<0.001
Log cystatin C, mg/L	9.592	<0.001
Equations for estimated GFR, mL/min^a
Cockcroft-Gault	−0.041	<0.001
CKD-EPI_creatinine	−0.076	<0.001
CKD-EPI_{cystatin C}	−0.094	<0.001
CKD-EPI_{creatinine-cystatin C}	−0.101	<0.001
Vancomycin parameters
Loading dose given	1.412	0.15
Total pre-trough dose, g	1.635	0.004
Interval
Every 8 hours	2.216	0.33
Every 12 hours	REF	-
Every 24 hours	−0.943	0.56

^aTo convert from mL/min per 1.73² multiply by [(0.007184*height (cm)^0.725*weight (kg)^0.425)/1.73] [37]. CKD-EPI, Chronic Kidney Disease Epidemiology Collaborative; GFR, glomerular filtration rate; REF, reference.

ISSN: 1364-8535