- Meeting abstract
- Open Access
PxV curve behavior inside and outside the thorax in normal rats
© The Author(s) 2001
- Published: 26 June 2001
- Public Health
- Animal Model
- Experimental Model
PxV curve is a good way to study the mechanical behavior of the respiratory system in animal models; however, it is important to distinguish between the behavior of the PxV curve inside the thorax (PxV curve of the respiratory system) and outside the thorax (PxV curve of the lung) as we studied in isolated lungs models.
In the 21 rats with closed thoracic cage the mean U-Pflex of the PxV curves was 13.5 ± 1.90. None of the 21 normal rats had L-Pflex. In contrast the isolated lungs showed a mean L-Pflex of 12.05 ± 3.03 and a mean U-Pflex 16.96 ± 2.93 (Figure).
The PxV curve has a completely different shape inside and outside the thorax, and this fact has to be taken into account during mechanical measurements in rats experimental models. FAPESP-LIM-FMUSP.