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Table 5 Complications of extracorporeal carbon dioxide removal

From: Extracorporeal carbon dioxide removal for patients with acute respiratory failure secondary to the acute respiratory distress syndrome: a systematic review

Study

Year

Modality

Complication rate (%)

Description

Forster and colleagues [25]

2013

VV (with CRRT)

Nil

 

Bein and colleagues [19]

2013

AV

7.5

1× lower limb ischaemia, 2× aneurysm

Nierhaus and colleagues [29]

2011

AV

21.4

2× catheter displacement, 1× bleeding at insertion site

Weber-Carstens and colleagues [26]

2009

AV

6.3

1× transient occlusion of femoral artery during cannulation

Zimmermann and colleagues [20]

2009

AV

11.8

3× lower limb ischaemia, 1× cannula thrombosis, 1× bleeding during cannulation, 1× compartment syndrome

Terragni and colleagues [21]

2009

VV

25

1× pump malfunction, 3× membrane/haemofilter clotting, 1× catheter displacement, 3× cannula problems

Muellenbach and colleagues [27]

2008

AV

23

2× lower limb ischaemia, 1× femoral artery pseudoaneurysm, 1× lower limb amputation, 1× catheter displacement

Bein and colleagues [28]

2006

AV

24.4

9× lower limb ischaemia, 4× cannula thrombosis, 4× compartment syndrome, 2× aneurysm, 1× haemolysis, 1× intracerebral haemorrhage, 1× diffuse bleeding with shock on cannulation

Liebold and colleagues [30]

2002

AV

21

7× cannula thrombosis, 1× membrane clotting, 3× lower limb ischaemia, 5× membrane plasma leakage

Guinard and colleagues [22]

1997

VV

NR

NR

Morris and colleagues [18]

1994

VV

NR

21× non-CNS haemorrhage (7 requiring discontinuation of ECCO2R), 4× circuit clotting

Brunet and colleagues [23]

1994

VV

18.2

1× alveolar haemorrhage, 1× diffuse bleeding

Bindslev and colleagues [31]

1991

VV

NR

1× allergic reaction

Gattinoni and colleagues [24]

1986

VV

NR

3× intra-pulmonary bleeding

  1. AV, arteriovenous; CNS, central nervous system; CRRT, continuous renal replacement therapy; ECCO2R, extracorporeal carbon dioxide removal; NR, not reported; VV, venovenous.