New insights into the mechanisms involved in B-type natriuretic peptide elevation and its prognostic value in septic patients

Papanikolaou, John; Makris, Demosthenes; Mpaka, Maria; Palli, Eleni; Zygoulis, Paris; Zakynthinos, Epaminondas

doi:10.1186/cc13864

Critical Care

Table 3 Clinical determinants of B-type natriuretic peptide in critical sepsis ( N = 42)^a

From: New insights into the mechanisms involved in B-type natriuretic peptide elevation and its prognostic value in septic patients

	Clinical determinants of BNP	Univariate linear regression analysis			Multivariate linear regression analysis
		r	R ²	P- value	β	Β (95% CI)	P-value
BNP (day 1)	APACHE II score	0.553	0.284	<0.001	0.066	9 (−15 to 33)	0.455
	SOFA score	0.662	0.438	<0.001	0.176	42.6 (−4 to 90)	0.073
	Noradrenaline dose	0.886	0.784	<0.001	0.731	33.4 (23 to 44)	<0.001
	LVSWI score	0.417	0.174	0.006	−0.003	−0.2 (−12 to 12)	0.968
	RVEF	−0.490	0.240	0.001	−0.02	−1.9 (−20 to 16)	0.829
BNP (day 2)	APACHE II score	0.557	0.310	<0.001	0.154	26.7 (−15 to 69)	0.207
	SOFA score	0.639	0.409	<0.001	0.233	72.5 (−9 to 154)	0.080
	Noradrenaline dose	0.762	0.58	<0.001	0.502	29.4 (11 to 48)	0.003
	LVEF	−0.363	0.132	0.009	−0.138	−9.3 (−28 to −9)	0.312
	LVSWI score	0.389	0.151	0.011	−0.038	−3.4 (−25 to 18)	0.745
	RVEF	−0.486	0.236	0.001	0.031	−3.9 (−34 to 42)	0.835
BNP (day 3)	APACHE II score	0.645	0.416	<0.001	0.262	40.6 (6 to 75)	0.022
	SOFA score	0.708	0.502	<0.001	0.254	68 (0 to 138)	0.05
	Noradrenaline dose	0.775	0.601	<0.001	0.430	23.8 (7 to 41)	0.007
	LVEF	−0.379	0.143	0.009	−0.112	−6.5 (−21 to 8)	0.373
	LVSWI score	0.353	0.125	0.027	−0.002	−0.14 (−17 to 17)	0.987
	RVEF	−0.504	0.254	0.001	−0.031	−3.7 (−35 to 28)	0.815
BNP (day 4)	APACHE II score	0.703	0.494	<0.001	0.263	42.4 (0 to 85)	0.05
	SOFA score	0.678	0.459	<0.001	0.191	47.6 (−20 to 115)	0.161
	Noradrenaline dose	0.801	0.642	<0.001	0.449	24.9 (8 to 42)	0.006
	RVEF	−0.467	0.218	0.003	−0.133	−15.7 (−41 to 10)	0.223
BNP (day 5)	APACHE II score	0.688	0.446	<0.001	0.334	52.9 (7 to 99)	0.025
	SOFA score	0.662	0.438	<0.001	0.255	55.6 (−9 to 120)	0.089
	Noradrenaline dose	0.720	0.518	<0.001	0.295	15.2 (−2 to 32)	0.083
	LVEF	−0.363	0.131	0.022	−0.192	−19.4 (−50 to 11)	0.203
	RVEF	−0.485	0.235	0.003	−0.029	−1.4 (−16 to 13)	0.843

^aAPACHE II, Acute Physiology and Chronic Health Evaluation Score II; B,β, Unstandardized and standardized β coefficients, respectively; BNP, B-natriuretic peptide; CI = Confidence interval; LVEF, Left ventricular ejection fraction; LVSWI, Left Ventricular Stroke Work Index; Noradrenaline dose, Peak noradrenaline dose on day 1; r = Pearson’s correlation coefficient; R² = Coefficient of determination; RVEF, Right ventricular ejection fraction; SOFA, Sequential Organ Failure Assessment. Clinical parameters associated significantly with serial BNP measurements on univariate analysis and independent determinants of BNP on the corresponding multivariate regression models.

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