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Table 2 Echocardiographic, hemodynamic data and serial B-type natriuretic peptide measurements in septic shock patients ( N = 30), severe sepsis patients ( N = 12) and hemorrhagic shock patients ( N = 11)a

From: New insights into the mechanisms involved in B-type natriuretic peptide elevation and its prognostic value in septic patients

 

Septic shock (N = 30)

Severe sepsis (N = 12)

Hemorrhagic shock (N = 11)

P- value (one-way ANOVA)

Ventricular systolic function on day 1

 LVEF, %

63.97 ± 2.28

60 ± 2.46

72.45 ± 1.67

0.021b

  LVEF ≥50%

26 (86.67)

11 (91.67)

10 (90.91)

0.439

  LVEF ≥35% to 49%

3 (10)

1 (8.33)

1 (9.09)

  LVEF <35%

1 (3.33)

0

0

 RVEF, %

32.83 ± 6.52

36.25 ± 1.26

41.73 ± 1.81

<0.001c

  RVEF ≥40%

7 (23.33)

2 (16.67)

8 (72.73)

0.004c

  RVEF ≥30% to 39%

13 (43.33)

9 (75)

3 (27.27)

  RVEF <30%

10 (33.33)

1 (8.33)

0

Baseline hemodynamic measurements

 mABP, mmHg

69.5 ± 1.4

74.17 ± 3

75 ± 1.13

0.072

 mPAP, mmHg

24.3 ± 0.73

23.33 ± 0.88

19.27 ± 1.48

0.004c

 SVI, ml/m2

39.12 ± 1.52

44.44 ± 2.06

31.14 ± 1.18

<0.001b,c

 CI, L/min/m2

4.56 ± 0.16

4.37 ± 0.17

3.44 ± 0.13

<0.001b,c

 SVRI, dyn/s/cm5/m2

1,078.2 ± 46.1

1,183.1 ± 60.4

1,580.2 ± 64.3

<0.001b,c

 PVRI, dyn/s/cm5/m2

221.38 ± 17.3

185.3 ± 24.1

229.03 ± 31.97

0.466

 LVSWI, g/m/m2

30.6 ± 1.4

37.1 ± 2.3

27.7 ± 1.1

0.013b,d

Serial PCWP and CVP measurements, mmHg

 PCWP (day 1)

12 ± 0.62

13.5 ± 0.64

9.55 ± 0.92

0.013b

 PCWP (day 2)

13.8 ± 0.53

13.92 ± 0.54

11.36 ± 0.73

0.027c

 PCWP (day 3)

13.5 ± 0.50

14.08 ± 0.48

12.3 ± 0.86

0.222

 CVP (day 1)

9.67 ± 0.54

10.25 ± 0.43

7.82 ± 0.58

0.056

 CVP (day 2)

9.64 ± 0.42

10.17 ± 0.30

9.35 ± 0.56

0.13

CVP (day 3)

10.73 ± 0.6

10.95 ± 0.57

9.64 ± 0.69

0.464

Serial BNP measurements, pg/ml

  

 BNP (day 1)

1,145.57 ± 101.43

311.33 ± 41.57

56.82 ± 17

0.001c,d

 BNP (day 2)

1,232.6 ± 142.37

320.67 ± 39.02

56.4 ± 12.17

0.001b,c,d

 BNP (day 3)

1,062.52 ± 136.68

290.75 ± 42.84

74.8 ± 21.1

0.001c,d

 BNP (day 4)

944.77 ± 156.01

288.92 ± 54.88

42 ± 13.58

0.002c,d

 BNP (day 5)

778.84 ± 145.82

257 ± 64.66

34.17 ± 10.76

0.002c,d

  1. aANOVA, Analysis of variance; BNP, B-natriuretic peptide; CI, Cardiac index; CVP, Central venous pressure; LVEF, Left ventricular ejection fraction; LVSWI, Left Ventricular Stroke Work Index; mABP, Mean arterial blood pressure; mPAP, Mean pulmonary artery pressure; PCWP, Pulmonary capillary wedge pressure; PVRI, Pulmonary Vascular Resistance Index; RVEF, Right ventricular ejection fraction; SVI, Stroke volume index; SVRI, Systemic vascular resistance index. bP < 0.05, severe sepsis vs. hemorrhagic shock; cP < 0.05, septic shock vs. hemorrhagic shock; and dP < 0.05, septic shock vs. severe sepsis (all with Bonferroni post hoc analysis). Continuous data are presented as means ± SE, and categorical data are expressed as n (%).