Protocol for gastrointestinal perforation with associated septic shock. The protocol for early infectious source control (EISC) and early goal-directed therapy (EGDT) for gastrointestinal perforation with septic shock was implemented at Nihon University Itabashi Hospital. GI, gastrointestinal; SIRS: systemic inflammatory response syndrome; IVF, intravenous fluids; CVP, central venous pressure; MAP, mean arterial pressure; ScvO2, central venous oxygen saturation. Revised points from the original protocol of Rivers et al. ; *in mechanical ventilation control, the target CVP is ≥8 mm Hg; **the original protocol specified dobutamine, but this was not used; ***blood gas analysis (BGA) measurement of ScvO2 in blood drawn from the internal jugular vein via an indwelling catheter.