Figure 1
From: A systematic review of therapeutic hypothermia for adult patients following traumatic brain injury
Death at final follow-up. (a) In total 18 trials involving 1,839 patients reported deaths. When the results of the 18 randomised controlled trials (RCTs) were statistically aggregated, therapeutic hypothermia was associated with a significant reduction in mortality (relative risk (RR) = 1.31, 95% CI = 1.13, 1.52, P = 0.0004). (b) Trials assessed as having lower risk of bias: when the results of the 14 RCTs were statistically aggregated, therapeutic hypothermia was associated with a significant reduction in mortality (RR = 1.62, 95% CI = 1.30, 2.01, P <0.0001).