The renal angiopoietin/Tie2 system in lethal human sepsis

Table 1 Patient characteristics

Patient	Age, years	Diagnosis	LOS in ICU, days	RIFLE	RRT needed?	Time to biopsy, minutes^a	Number of glomeruli^b	Predominant histology^c
1	85	Small bowl ischemia	3	R	No	32	61	Apoptosis, flattened epithelium, vacuoles
2	62	Pneumosepsis	1	I	No	25	24	Apoptosis, flattened epithelium
3	55	Pneumosepsis	2	I	Yes	30	40	Little apoptosis, flattened epithelium, vacuoles
4	62	Necrotizing fasciitis	2	F	No	150	22	Focally lymphoid infiltration, evident vacuolization, flattened epithelium
5	57	Colon perforation	2	F	Yes	31	15	Dilated glomerular capillaries, vacuolization
6	83	Small bowel ischemia	1	I	No	45	26	Apoptosis, vacuolization
7	78	Pneumonia	2	F	Yes	25	19	Focally leukocyte infiltration, apoptosis, flattened epithelium
8	79	Necrotizing fasciitis	6	F	No	43	47	Apoptosis, flattened and lost epithelium, vacuolization
9	77	Pneumonia	3	F	No	50	22	Apoptosis, flattened epithelium
10	53	Pneumonia	2	F	Yes	35	69	Apoptosis, flattened epithelium
11	83	Sinusitis, meningitis	2	F	Yes	53	27	Neutrophil infiltration (nodular), vacuolization

^aTime between circulation arrest and renal biopsy; ^bnumber of glomeruli found in the histology of the biopsy; ^cpathologic conclusion of the histology of the biopsies (performed by MH and AD). LOS in ICU, length of stay in the intensive care unit; RIFLE, Risk, Injury, Failure, Loss, End-stage kidney injury; RRT, renal replacement therapy.

ISSN: 1364-8535