Figure 1

Multivariable generalised additive model and piecewise linear model for relationship between fibrinogen concentration and 28-day survival. Results from the multivariable generalised additive model (GAM) and the piecewise linear model for the relationship between fibrinogen concentration and 28-day survival, adjusted for Injury Severity Score, age, time from injury, mechanism of injury, base excess, International Normalized Ratio, platelet count and gender. The functional relationship is clearly nonlinear (a), resulting in a corresponding nonconstant odds ratio across the observed range of fibrinogen values (b). For the piecewise linear model, the breakpoint (95% confidence interval (CI)) is estimated at 2.29 (1.93, 2.64).