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Table 5 Evolution of acid base parameters in arterial blood during the study period a

From: Half-molar sodium lactate infusion improves cardiac performance in acute heart failure: a pilot randomised controlled clinical trial

Time point pH PaCO2 PaO2 HCO3- BE Lactate
Baseline       
  Control (n = 21) 7.37 ± 0.1 40 ± 13 98 ± 33 22.8 ± 4.9 -1.7 ± 5.6 1.4 ± 0.5
  Lactate (n = 19) 7.40 ± 0.06 36 ± 9 103 ± 28 23.3 ± 3.3 -0.3 ± 4.1 2.4 ± 2.3
Post-bolus       
  Control (n = 21) 7.37 ± 0.09 40 ± 9 91 ± 19 23.1 ± 5.1 -1.01 ± 5.7 2 ± 1.4
  Lactate (n = 19) 7.45 ± 0.05b,c 38 ± 8 95 ± 30 25.9 ± 4.1b 2.7 ± 4.2 4.8 ± 2.0b
6 hours       
  Control (n = 20) 7.38 ± 0.06 42 ± 9 93 ± 27 24.1 ± 4.8 -0.7 ± 5.3 1.6 ± 1.2
  Lactate (n = 19) 7.49 ± 0.04b,c 43 ± 5b 87 ± 24 32.5 ± 4.8b,c 8.9 ± 4.5b,c 2.9 ± 1.0c
12 hours       
  Control (n = 19) 7.38 ± 0.07 42 ± 10 95 ± 37 24.3 ± 4.7 -0.2 ± 5.2 1.4 ± 0.6
  Lactate (n = 19) 7.51 ± 0.04b,c 47 ± 5b 82 ± 24 37.1 ± 5.3b,c 12.9 ± 4.6 3.1 ± 1.6c
24 hours       
  Control (n = 19) 7.41 ± 0.07 38 ± 11 84 ± 20 23.9 ± 5.4 -0.9 ± 5.8 1.5 ± 1.0
  Lactate (n = 18) 7.53 ± 0.03b,c 51 ± 7b,c 81 ± 26 41.4 ± 6.3b,c 16.8 ± 4.8b,c 2.3 ± 0.8c
48 hours       
  Control (n = 18) 7.42 ± 0.03 42 ± 9 87 ± 28 26.9 ± 5.6b 2.8 ± 5.3b 1.6 ± 0.9
  Lactate (n = 18) 7.47 ± 0.03b 48 ± 4b 95 ± 42 34.2 ± 4.1b,c 9.6 ± 4.2b,c 1.2 ± 0.5b
  1. aBE = Base excess (mmol/L); HCO3-= Bicarbonate (mmol/L); PaCO2 = Partial pressure of carbon dioxide (mmHg); PaO2 = Partial pressure of oxygen (mmHg). bP < 0.01 compared to baseline values and cP < 0.01 for intergroup comparison. Data are expressed as mean ± SD.