Half-molar sodium lactate infusion improves cardiac performance in acute heart failure: a pilot randomised controlled clinical trial

Table 5 Evolution of acid base parameters in arterial blood during the study period ^a

Time point	pH	PaCO₂	PaO₂	HCO₃^-	BE	Lactate
Baseline
Control (n = 21)	7.37 ± 0.1	40 ± 13	98 ± 33	22.8 ± 4.9	-1.7 ± 5.6	1.4 ± 0.5
Lactate (n = 19)	7.40 ± 0.06	36 ± 9	103 ± 28	23.3 ± 3.3	-0.3 ± 4.1	2.4 ± 2.3
Post-bolus
Control (n = 21)	7.37 ± 0.09	40 ± 9	91 ± 19	23.1 ± 5.1	-1.01 ± 5.7	2 ± 1.4
Lactate (n = 19)	7.45 ± 0.05^b,c	38 ± 8	95 ± 30	25.9 ± 4.1^b	2.7 ± 4.2	4.8 ± 2.0^b
6 hours
Control (n = 20)	7.38 ± 0.06	42 ± 9	93 ± 27	24.1 ± 4.8	-0.7 ± 5.3	1.6 ± 1.2
Lactate (n = 19)	7.49 ± 0.04^b,c	43 ± 5^b	87 ± 24	32.5 ± 4.8^b,c	8.9 ± 4.5^b,c	2.9 ± 1.0^c
12 hours
Control (n = 19)	7.38 ± 0.07	42 ± 10	95 ± 37	24.3 ± 4.7	-0.2 ± 5.2	1.4 ± 0.6
Lactate (n = 19)	7.51 ± 0.04^b,c	47 ± 5^b	82 ± 24	37.1 ± 5.3^b,c	12.9 ± 4.6	3.1 ± 1.6^c
24 hours
Control (n = 19)	7.41 ± 0.07	38 ± 11	84 ± 20	23.9 ± 5.4	-0.9 ± 5.8	1.5 ± 1.0
Lactate (n = 18)	7.53 ± 0.03^b,c	51 ± 7^b,c	81 ± 26	41.4 ± 6.3^b,c	16.8 ± 4.8^b,c	2.3 ± 0.8^c
48 hours
Control (n = 18)	7.42 ± 0.03	42 ± 9	87 ± 28	26.9 ± 5.6^b	2.8 ± 5.3^b	1.6 ± 0.9
Lactate (n = 18)	7.47 ± 0.03^b	48 ± 4^b	95 ± 42	34.2 ± 4.1^b,c	9.6 ± 4.2^b,c	1.2 ± 0.5^b

^aBE = Base excess (mmol/L); HCO₃^- = Bicarbonate (mmol/L); PaCO₂ = Partial pressure of carbon dioxide (mmHg); PaO₂ = Partial pressure of oxygen (mmHg). ^bP < 0.01 compared to baseline values and ^cP < 0.01 for intergroup comparison. Data are expressed as mean ± SD.

ISSN: 1364-8535