Table 1 Synopsis of randomized controlled trials comparing protective versus conventional lung ventilation strategy during general anesthesia.
From: Protective lung ventilation during general anesthesia: is there any evidence?
| Â | Â | Â | Â | Ventilatory strategy | Â | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | VT (ml/kg) | PEEP (cmH2O) | Recruitment maneuver (Yes/No) | Â | |||
|  | First author [ref] | Year | N° pts | Case | Control | Case | Control | Case | Control | Outcomes |
Abdominal | Wriggw [21] | 2000 | 39 | 66 | 15 | 0 | 0 | No | No | Systemic IL-6, IL-10, TNF-α: similar |
| Â | Â | Â | Â | 6 | Â | 10 | Â | Â | Â | Â |
|  | Wrigge [22] | 2004 | 30 | 6 | 12-15 | 10 | 0 | No | No | Systemic/pulmonary IL-8-1-6-10-12, TNF-α: similar |
| Â | Determann [23] | 2008 | 40 | 6 | 12 | 10 | 0 | No | No | Lung epithelial injury biomarkers: similar |
| Â | Weingarten [25] | 2010 | 40 | 6 | 10 | 12 | 0 | Yes | No | Intraoperative PaO2, Lung mechanics: better Systemic IL-8, IL-6: similar |
| Â | Treschen [24] | 2012 | 101 | 6 | 12 | 5 | 5 | No | No | Postoperative dynamic spirometry: similar |
| Â | Severgnini [26] | 2013 | 56 | 7 | 9 | 10 | 0 | Yes | No | Clinical Pulmonary Infection Score: lower Postoperative respiratory function: better |
| Â | Futier [27] | 2013 | 400 | 6-8 | 10-12 | 6-8 | 0 | Yes | No | Pulmonary/extrapulmonary complications: lower Hospital stay: shorter |
|  | PROVHILO [28] | - | 900 | <8 | <8 | 12 | ≤ 2 | Yes | No | Postoperative pulmonary complications |
Thoracic | Schilling [33] | 2005 | 32 | 5 | 10 | 0 | 0 | No | No | Pulmonary TNF-α, IL-8, IL-10: lower TNF-α |
|  | Michelet [36] | 2006 | 52 | 5 | 9 | 5 | 0 | No | No | Systemic IL-1β, IL-6, IL-8: lower Oxygenation: better Postoperative MV length: shorter |
| Â | Yang [35] | 2011 | 100 | 6 | 10 | 5 | 0 | No | No | Oxygenation: better Postoperative pulmonary complications: lower |
Cardiac | Chaney [49] | 2000 | 25 | 6 | 12 | 5 | 5 | No | No | Postoperative lung mechanics: better |
|  | Koner [42] | 2004 | 44 | 6 | 10 | 5 | 0 | No | No | Systemic IL-6, TNF-α: similar |
| Â | Â | Â | Â | Â | 10 | Â | 5 | Â | Â | Hospital LOS: similar Postoperative pulmonary function: similar |
| Â | Zupancich [44] | 2005 | 40 | 8 | 10-12 | 10 | 2-3 | No | No | Pulmonary and systemic Il-6, IL-8: lower |
|  | Reis [47] | 2005 | 62 | 4-6 | 6-8 | 10 | 5 | Yes | No | Systemic Il-8, IL-10: lower Systemic IL-6, TNF-α, IFN-γ: similar |
| Â | Reis [48] | 2005 | 69 | 4-6 | 6-8 | 10 | 5 | Yes | No | Postoperative hypoxemia: lower Postoperative FRC: better |
|  | Wrigge [41] | 2005 | 44 | 6 | 12 | 9* | 7* | No | No | Systemic TNF-α, IL-6-8-2-4-10: similar Pulmonary TNF-#945;, IL-6-8-2-4-10: lower TNF-α |
| Â | Sundar [43] | 2011 | 149 | 6 | 10 | 5* | 4.9* | No | No | Time to extubation: similar Extubation at 6-8 h after surgery: better Reintubation: lower |