Calorie intake and patient outcomes in severe acute kidney injury: findings from The Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy (RENAL) study trial

Table 4 Multivariable linear regression for secondary outcomes*

Variable name	Estimate	Standard error	P-value
a. Multivariable linear regression for RRT-free days
Intercept	−40.32510	33.71933	0.2323
Mean daily calorie intake during ICU admission	0.00189	0.00171	0.2695
Median daily calorie intake during ICU admission	−1.09792	2.61145	0.6744
Positive mean fluid balance	−4.09805	0.87492	<.0001
Treatment	−1.97170	0.85163	0.0210
Time from ICU admission to randomization (in days)	−0.01644	0.00469	0.0005
SOFA liver (score)	−1.63540	0.44579	0.0003
APPT	−0.05581	0.02105	0.0083
pH	8.45062	4.27094	0.0484
b. Multivariate linear regression of ICU-free days
Intercept	−221.76773	281.51940	0.4313
Mean daily calorie intake during ICU admission	0.00468	0.00649	0.4714
Median daily calorie intake during ICU admission	2.89089	8.90361	0.7456
Positive mean fluid balance	−19.69578	3.36383	<.0001
Positive ventilation: no = reference group	−13.45268	5.58339	0.0165
Patient's weight (Kg)	0.45320	0.13896	0.0012
Time from ICU admission to randomization (days)	−0.03736	0.01756	0.0340
Last creatinine concentration	0.11279	0.04434	0.0114
c. Multivariate linear regression of hospital-free days
Intercept	25.05875	258.60573	0.9229
Mean daily calorie intake during ICU admission	−0.00349	0.00601	0.5625
Median daily calorie intake during ICU admission	2.11260	8.32222	0.7997
Positive mean fluid balance	−16.17529	3.08521	<.0001
Patient's weight (Kg)	0.29499	0.12933	0.0231
Last serum urea concentration	−3.72244	1.85441	0.0454
Last creatinine concentration	0.09767	0.04131	0.0185
Glucose (mmol/L)	1.09456	0.50830	0.0319

*Only DCI related variable and significant variables reported. SOFA, sequential organ failure assessment; activated partial thromboplastin time.

ISSN: 1364-8535