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Table 5 Plasma and urinary concentrations of NGAL, BNP and, for comparison, serum and urinary concentrations of various markers of GFR impairment and urinary excretion of tubular enzymes, according to the etiologies of kidney disease

From: Effect of glomerular filtration rate impairment on diagnostic performance of neutrophil gelatinase-associated lipocalin and B-type natriuretic peptide as markers of acute cardiac and renal failure in chronic kidney disease patients

 

Potential kidney donors

Kidney donors

Renal transplant recipients

Chronic glomerulonephritis

Chronic kidney disease

Ischemic interstitial nephropathy

Diabetic nephropathy

Number

33

45

42

50

63

29

36

Age (years)

50.2 ± 1.6

53.0 ± 1.6

41.8 ± 1.7***++++

43.2 ± 2.2*

55.5 ± 1.7*

58.1 ± 2.8*

49.9 ± 2.7

GFR (ml/minute/1.73 m2)

96.5 ± 3.6

62.4 ± 2.5****

47.4 ± 2.3****++++

58.6 ± 4.2****

38.3 ± 3.3****++++

43.5 ± 5.7****++

65.1 ± 6.5**++

Plasma NGAL (ng/ml)

55.9 ± 5.3

112.4 ± 11.3****

242.6 ± 34.6****+++

272.9 ± 50.1****++

456.8 ± 50.87****++++

371.1 ± 64.9****+++

215.6 ± 31.0****++

Plasma BNP (pg/ml)

19.1 ± 4.4

20.2 ± 0.9

56 ± 12.3**++

16.6 ± 3.1

35.9 ± 6.4**++

79.3 ± 31.6

48.2 ± 8.8**++

Serum creatinine (mg/dl)

0.8 ± 0.03

1.2 ± 0.04****

1.7 ± 0.1****++++

1.8 ± 0.2****++

2.6 ± 0.2****++++

2.2 ± 0.3***++

1.6 ± 0.13**+

Serum cystatin C (mg/l)

0.7 ± 0.03

1.1 ± 0.11****

1.6 ± 0.1****++++

1.6 ± 0.1****++

2.1 ± 0.1****++++

2.1 ± 0.3****+++

1.5 ± 0.1***+

Serum β2-microglobulin (mg/l)

1.2 ± 0.04

1.9 ± 0.04****

3.0 ± 0.3****++

3.1 ± 0.4****++

4.8 ± 0.4****++++

4.4 ± 0.7***++

2.8 ± 0.3***++

Urinary NGAL (ng/ml)

12.4 ± 4.6

10.1 ± 2.7

21.1 ± 7.0

27.3 ± 7.2+

45.3 ± 9.9**+++

17.4 ± 5.3

13.8 ± 3.4

Urinary albumin (mg/dl)

6.3 ± 4.3

1.6 ± 0.4

16.4 ± 8.4

184 ± 49***+++

52.9 ± 8.4****++++

60.0 ± 18.3**++

36.2 ± 11.2*

Urinary cystatin C (mg/l)

0.1 ± 0.07

0.1 ± 0.04

0.2 ± 0.09

0.9 ± 0.47

0.6 ± 0.16*++

0.4 ± 0.14

0.1 ± 0.04

Urinary β2-microglobulin (mg/l)

0.1 ± 0.06

0.3 ± 0.08*

1.7 ± 0.5***++

3.7 ± 1.6*+

5.2 ± 1.5***++

3.1 ± 1.4*+

1.1 ± 0.3*

Urinary GGT (u/l)

68.7 ± 9.5

29.0 ± 2.7***

40.6 ± 6.4*

63.6 ± 6.0++++

38.0 ± 4.5**

47.0 ± 9.1

43.3 ± 6.7**

Urinary LDH (u/l)

29.0 ± 4.1

18.3 ± 2.6*

17.3 ± 2.0*

51.8 ± 12.6+

25.0 ± 2.4+

47.3 ± 19.1

31.2 ± 6.5

Urinary NAG (u/l)

5.3 ± 0.6

5.1 ± 0.8

5.6 ± 0.5

6.8 ± 0.6+

7.1 ± 0.6*++

7.0 ± 0.9

5.7 ± 0.8

  1. Mean values ± standard errors of the mean are reported. The significance of the differences with mean values of potential kidney donors and of kidney donors is indicated: *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; +P < 0.05; ++P < 0.01; +++P < 0.001; +++P < 0.0001. BNP, B-type natriuretic peptide; GGT, gamma-glutamyl-transferase; GFR, glomerular filtration rate; LDH, lactate dehydrogenase; NAG, N-acetyl-β-d-glucosaminidase; NGAL, neutrophil gelatinase-associated lipocalin.
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Critical Care

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