Effect of glomerular filtration rate impairment on diagnostic performance of neutrophil gelatinase-associated lipocalin and B-type natriuretic peptide as markers of acute cardiac and renal failure in chronic kidney disease patients

Table 3 Accuracy of blood and urinary concentrations of the different markers as indicators of different degrees of glomerular filtration rate impairment evaluated by means of receiver operating curves

	GFR < 90 ml/minute/1.73 m²	GFR <60 ml/minute/1.73 m²	GFR <45 ml/minute/1.73 m²	GFR <30 ml/minute/1.73 m²	GFR <15 ml/minute/1.73 m²
Plasma NGAL (ng/ml)
AUC	0.838*****	0.845*****	0.872*****	0.912*****	0.929*****
Criterion	>102	>136	>213	>214	>270
Sensitivity	69.8	77.4	77.0	92.1	100
Specificity	87.5	82.0	84.3	76.1	75.5
Plasma BNP (pg/ml)
AUC	0.613**	0.599**	0.588*	0.623**	0.579 NS
Criterion	>31.3	>51.9	>26.6	>26.6	>28.3
Sensitivity	34	25	48	54	50
Specificity	85	93	71	68	67
Serum creatinine (mg/dl)
AUC	0.895*****	0.908*****	0.943*****	0.977*****	0.990*****
Criterion	>1.01	>1.25	>1.55	>2.14	>3.08
Sensitivity	82.9	81.0	85.6	90.2	100
Specificity	85.6	81.7	89.2	96.7	94
Urinary NGAL (ng/ml)
AUC	0.555 NS	0.601**	0.617***	0.635****	0.773***
Criterion		>8.2	>14.4	>20.2	>22.0
Sensitivity		49	42	47.6	70
Specificity		68	80	83	81

Values of the areas under the curve (AUC), criterion values, and sensitivity and specificity values are reported. The statistical significance of the different AUCs is indicated. *P < 0.05; **P < 0.01; ***P < 0.001;****P < 0.00001. BNP, B-type natriuretic peptide; GFR, glomerular filtration rate; NGAL, neutrophil gelatinase-associated lipocalin.

ISSN: 1364-8535