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Table 5 Levels of soluble intercellular adhesion molecule-1 in neonates, children and adults

From: Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults

Study (reference)

Mean age

Sepsis criteria

Healthy (μg/ml)a

Number of patients (healthy)

Sepsis (μg/ml)a

Number of patients (sepsis)

Neonates

      

Figueras-Aloy and colleagues [49]

0 to 14 days

SNAP-II

215 (156 to 274)

12

426 (394 to 458)

15

Apostolou and colleagues [58]

At term

Clinical

358.4 ± 28.9

10

710.7 ± 56.6

10

Dollner and colleagues [52]

0 to 7 days

Clinical

244 (95.2 to 500)

24

413 (255.6 to 500)

18

Austgulen and colleagues [45]

Pre/at term

Clinical

258.8 (94 to 500)

168

394.2 (197.5 to 500)

24

Berner and colleagues [51]

0 to 3 days

Clinical

421 (291 to 459)

35

446 (171 to 534)

136

Edgar and colleagues [57]

0 to 7 days

Clinical

165 (130 to 290)

27

341 (236 to 554)

192

Edgar and colleagues [56]

0 to 7 days

Clinical

205

46

406

46

Children

      

Andrys and colleagues [60]

6 to 10

 

346.8 (206.8 to 486.8)

68

  
 

11 to 15

 

269 (184.1 to 354)

90

  

Paize and colleagues [61]

2 to 16

PRISM

260 (240 to 300)

40

705 (400 to 850)

20

Whalen and colleagues [63]

1 day to 17 years

Criteria of Doughty and colleaguesb

205 ± 29

14

595

77

Nash and colleagues [64]

9

 

310 (280 to 410)

81

  
 

15

 

300 (270 to 390)

   

Briassoulis and colleagues [19]

6.5 (2.8)

PRISM

199 ± 98

10

172 ± 93

10

Adults

      

Weigand and colleagues [66]

58.7 (4.4)

ACCP/SCCM

190

7

1,100

14

Soderquist and colleagues [70]

71 (10 to 91)

Unknown

202 (62 to 392)

15

451 (216 to 1,030)

41

Scherpereel and colleagues [77]

58.9 (14.9)

SAPS II

  

2,130

63

Hofer and colleagues [78]

65.9 (12.4)

APACHE II

219.6 (195.2 to 285.1)

108

444.7 (330 to 665.5)

18

De Pablo and colleagues [73]

61.2 (3.2)

APACHE II

480

36

1100

52

Kayal and colleagues [74]

57.2 (3.9)

ACCP/SCCM

208 ± 20.5

9

868 ± 131

25

Shapiro and colleagues [6]

57 (19)

APACHE III

185

207

240

13

Andrys and colleagues [60]

46

 

140 (60.2 to 218.4)

68

  

Leone and colleagues [76]

45 to 47 (16 to 21)

SIRS

151

26

824

11

  1. ACCP/SCCM, American college of chest physicians/ society of critical care medicine; APACHE, acute physiology and chronic health evaluation; PRISM, pediatric risk of mortality; SAPS, simplified acute physiology score; SIRS, systemic inflammatory response syndrome; SNAP, score for neonatal acute physiology. aData presented as mean (range) or mean ± standard deviation. bCriteria from [75]. Ages expressed in years unless otherwise stated.
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Critical Care

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