Skip to main content

Advertisement

Table 5 Levels of soluble intercellular adhesion molecule-1 in neonates, children and adults

From: Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults

Study (reference) Mean age Sepsis criteria Healthy (μg/ml)a Number of patients (healthy) Sepsis (μg/ml)a Number of patients (sepsis)
Neonates       
Figueras-Aloy and colleagues [49] 0 to 14 days SNAP-II 215 (156 to 274) 12 426 (394 to 458) 15
Apostolou and colleagues [58] At term Clinical 358.4 ± 28.9 10 710.7 ± 56.6 10
Dollner and colleagues [52] 0 to 7 days Clinical 244 (95.2 to 500) 24 413 (255.6 to 500) 18
Austgulen and colleagues [45] Pre/at term Clinical 258.8 (94 to 500) 168 394.2 (197.5 to 500) 24
Berner and colleagues [51] 0 to 3 days Clinical 421 (291 to 459) 35 446 (171 to 534) 136
Edgar and colleagues [57] 0 to 7 days Clinical 165 (130 to 290) 27 341 (236 to 554) 192
Edgar and colleagues [56] 0 to 7 days Clinical 205 46 406 46
Children       
Andrys and colleagues [60] 6 to 10   346.8 (206.8 to 486.8) 68   
  11 to 15   269 (184.1 to 354) 90   
Paize and colleagues [61] 2 to 16 PRISM 260 (240 to 300) 40 705 (400 to 850) 20
Whalen and colleagues [63] 1 day to 17 years Criteria of Doughty and colleaguesb 205 ± 29 14 595 77
Nash and colleagues [64] 9   310 (280 to 410) 81   
  15   300 (270 to 390)    
Briassoulis and colleagues [19] 6.5 (2.8) PRISM 199 ± 98 10 172 ± 93 10
Adults       
Weigand and colleagues [66] 58.7 (4.4) ACCP/SCCM 190 7 1,100 14
Soderquist and colleagues [70] 71 (10 to 91) Unknown 202 (62 to 392) 15 451 (216 to 1,030) 41
Scherpereel and colleagues [77] 58.9 (14.9) SAPS II    2,130 63
Hofer and colleagues [78] 65.9 (12.4) APACHE II 219.6 (195.2 to 285.1) 108 444.7 (330 to 665.5) 18
De Pablo and colleagues [73] 61.2 (3.2) APACHE II 480 36 1100 52
Kayal and colleagues [74] 57.2 (3.9) ACCP/SCCM 208 ± 20.5 9 868 ± 131 25
Shapiro and colleagues [6] 57 (19) APACHE III 185 207 240 13
Andrys and colleagues [60] 46   140 (60.2 to 218.4) 68   
Leone and colleagues [76] 45 to 47 (16 to 21) SIRS 151 26 824 11
  1. ACCP/SCCM, American college of chest physicians/ society of critical care medicine; APACHE, acute physiology and chronic health evaluation; PRISM, pediatric risk of mortality; SAPS, simplified acute physiology score; SIRS, systemic inflammatory response syndrome; SNAP, score for neonatal acute physiology. aData presented as mean (range) or mean ± standard deviation. bCriteria from [75]. Ages expressed in years unless otherwise stated.