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Table 1 Characteristics of adhesion molecules involved in sepsis

From: Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults

Adhesion molecule Expression Ligands Inflammatory mediators Mode of expression Specific function Sheddase
E-selectin Endothelial cells ESLG-1, PSGL-1 TNFα, LPS, IL-1 Inducible Rolling Caspase
L-selectin Leukocytes GlyCAM-1, MAdCAM-1 TNFα, LPS, IL-1, IL-6 Constitutive, inducible Rolling ADAM-17
P-selectin Endothelial cells, platelets PSGL-1 TNFα, IL-4, IL-13, histamine, thrombin Constitutive Rolling MMP
ICAM-1 Endothelial cells Mac-1, LFA-1 TNFα, LPS, IL-1 Constitutive, inducible Firm adhesion, TEM ADAM-17, NE
VCAM-1 Endothelial cells VLA-4 TNFα, LPS, IL-1 Constitutive, inducible Firm adhesion, TEM ADAM-17, NE
  1. ADAM, a disintegrin and metalloproteinase; ESGL-1, endothelial selectin glycoprotein ligand; GlyCAM-1, glycosylation dependent cell adhesion molecule; ICAM-1, intercellular adhesion molecule-1; IL, interleukin; LFA, leukocyte function antigen; LPS, lipopolysaccharide; Mac, macrophage antigen; MAdCAM, mucosal vascular addressin cell adhesion molecule; MMP, matrix metalloproteinase; NE, neutrophil elastase; PSGL, platelet selectin glycoprotein ligand; TEM, transendothelial migration; TNF, tumor necrosis factor; VCAM-1, vascular cell adhesion molecule-1; VLA, very late antigen.