Table 2 Clinical characteristics of the patients in the validation study in survivors and non-survivors at 28 days
From: Circulating neutrophil counts and mortality in septic shock
Total (n = 194) | Survivors (n = 132) | Non-survivors (n = 62) | P | |
|---|---|---|---|---|
Patient details | ||||
Gender (male) | 126 (64.9%) | 85 (64.3%) | 41 (66.1%) | NS |
Age (years) | 67.1 ± 13.3 | 65.3 ± 14.3 | 71.1 ± 9.5 | <0.001 |
Inmunosuppression | 35 (18.0%) | 15 (11.3%) | 20 (32.2%) | <0.001 |
Diabetes | 32 (16.4%) | 21 (15.9%) | 11 (17.7%) | NS |
Cardiovascular disease | 24 (12.3%) | 14 (10.6%) | 10 (16.1%) | NS |
Cancer | 18 (9.2%) | 10 (7.5%) | 8 (12.9%) | NS |
COPD | 23 (11.8%) | 12 (9.0%) | 11 (17.7%) | NS |
Chronic renal failure | 15 (7.7%) | 10 (7.5%) | 5 (8.0%) | NS |
Alcohol abuse | 12 (6.1%) | 7 (5.3%) | 5 (8.0%) | NS |
Hepatic disease | 4 (2.0%) | 1 (0.7%) | 3 (4.8%) | NS |
Clinical status at admission | ||||
APACHE II score | 22.6 ± 7.0 | 21.0 ± 6.5 | 25.9 ± 7.1 | <0.001 |
Mechanical ventilation | 150 (77.7%) | 93 (70.9%) | 57 (91.9%) | <0.001 |
OARF | 39 (20.1%) | 17 (12.8%) | 22 (35.4%) | <0.001 |
Presumed source of infection | ||||
Respiratory system | 67 (34.5%) | 45 (34.1%) | 22 (35.5%) | NS |
Digestive system | 52 (26.8%) | 32 (24.2%) | 20 (32.3%) | NS |
Urinary system | 26 (13.4%) | 21 (15.9%) | 5 (8.1%) | NS |
Catheter | 16 (8.2%) | 11 (8.3%) | 5 (8.1%) | NS |
Wound/skin, soft tissue | 15 (7.7%) | 11 (8.3%) | 4 (6.5%) | NS |
Other/unknown | 18 (9.3%) | 12 (9.1%) | 6 (9.7%) | NS |
Documented microbial agent | ||||
Gram-negative | 52 (26.8%) | 36 (27.2%) | 16 (25.8%) | NS |
Gram-positive | 33 (17.0%) | 25 (18.9%) | 8 (12.9%) | NS |
Fungi | 12 (6.1%) | 4 (3.0%) | 8 (12.9%) | 0.020 |
Laboratory data | ||||
Bilirubin (mg/dL) | 1.4 ± 2.2 | 1.4 ± 2.1 | 1.6 ± 2.4 | NS |
Glycemia (mg/dL) | 168 ± 64.0 | 167 ± 62.4 | 172.0 ± 67.6 | NS |
INR | 1.8 ± 3.1 | 1.9 ± 3.8 | 1.6 ± 0.6 | NS |
Platelets (×103/μl) | 177.4 ± 118.5 | 173.6 ± 105.2 | 186.4 ± 146.1 | NS |
Leukocytes (×103/μl) | 18.0 ± 16.4 | 18.4 ± 17.0 | 17.3 ± 15.3 | NS |
Monocytes (×103/μl) | 0.7 ± 1.7 | 0.8 ± 20.2 | 0.6 ± 0.9 | NS |
Lymphocyte (×103/μl) | 1.8 ± 70.5 | 1.6 ± 73.5 | 2.3 ± 64.1 | NS |
Neutrophils (×103/μl) | 14.9 ± 12.5 | 15.6 ± 12.9 | 13.6 ± 11.5 | NS |
Basophils (×103/μl) | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | NS |
Eosinophils (×103/μl) | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | NS |