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Table 4 Results of univariable and multivariable logistic regression analyses for factors associated with 90-day mortality in patients with septic shock

From: Variation in the use of renal replacement therapy in patients with septic shock: a substudy of the prospective multicenter observational FINNAKI study

 

Univariable analyses

Multivariable analyses

Propensity score4adjusted multivariable analyses

 

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

Age

    

Not included

 

  45–54 years1

1.54 (0.7–3.37)

0.28

1.76 (0.73–4.28)

0.21

  55–64 years1

1.9 (0.94–3.82)

0.08

2.09 (0.95–4.6)

0.07

  65–74 years1

4.06 (2.06–8.02)

<0.001

5.52 (2.57–11.89)

<0.001

  ≥75 years1

5.62 (2.86–11.04)

<0.001

8.26 (3.83–17.81)

<0.001

Operative admission

0.57 (0.4–0.81)

0.002

0.63 (0.42–0.96)

0.03

0.6 (0.4–0.89)

0.01

SAPS II without age and renal points

1.05 (1.04–1.07)

<0.001

1.05 (1.03–1.07)

<0.001

Not included

 

Renal failure within the first day on the ICUs

3.17 (2.16–4.66)

<0.001

1.91 (1.1–3.31)

0.02

Not included

 

Mechanical ventilation

1.91 (1.27–2.87)

0.002

1.26 (0.76–2.09)

0.38

1.77 (1.12–2.77)

0.01

Highest norepinephrine dose (μg/kg/min)2

2.74 (1.92–3.91)

<0.001

1.02 (1.01–1.03)

<0.001

1.02 (1.01–1.02)

<0.001

Lowest BE value3

0.94 (0.92–0.96)

<0.001

0.98 (0.95–1.01)

0.11

0.97 (0.94–1.0)

0.05

High RRT ICU group

1.11 (0.82–1.5)

0.52

0.89 (0.59–1.34)

0.57

0.88 (0.6–1.29)

0.50

RRT*RRT group (interaction term)

1.97 (1.28–3.02)

0.02

0.67 (0.24–1.85)

0.43

0.7 (0.27–1.79)

0.45

  1. 1Compared to patients under 44 years of age; 2the highest norepinephrine dose during the first five days in the ICU; 3the lowest BE value 24 hours prior to ICU admission or within the first 24 hours in the ICU; 4confounders entered to the propensity score: creatinine value on the first day in the ICU (D1), urine output on the D1, age groups according to APACHE II score, any comorbidity, SAPS II score without age and renal components and SOFA score without renal points on the D1. OR odds ratio; CI, confidence interval; SAPS II, Simplified Acute Physiology Score II; RRT, renal replacement therapy; ICU, intensive care unit.
  2. Multivariable model without the propensity score: Hosmer-Lemeshow P = 0.59 and -2 log likelihood = 738.8. Multivariable model with the propensity score: Hosmer-Lemeshow P = 0.46 and -2 log likelihood =800.2.