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Table 2 Comparison of organ failures and organ-supportive treatments between high- and low-renal replacement therapy (RRT) intensive care units (ICUs)

From: Variation in the use of renal replacement therapy in patients with septic shock: a substudy of the prospective multicenter observational FINNAKI study

 

Low RRT-ICUs (n = 372)

High RRT-ICUs (n = 354)

P value

Septic shock on ICU admission

109 (29.3)

138 (39.0)

0.006

Any AKI

196 (52.7)

240 (67.8)

<0.001

KDIGO stage 1

85 (22.8)

82 (23.2)

0.9

KDIGO stage 2

41 (11.0)

43 (12.1)

0.6

KDIGO stage 3

70 (18.8)

115 (32.5)

<0.001

KDIGO 3 stage without RRT

37 (9.9)

17 (4.8)

0.008

Cardiovascular failure on D1

317 (85.2)

336 (94.9)

<0.001

Respiratory failure on D1

193 (51.9)

179 (50.6)

0.7

Renal failure on D1

53 (14.2)

81 (22.9)

0.003

Liver failure on D1

4 (1.1)

8 (2.3)

0.2

Coagulation failure on D1

24 (6.5)

33 (9.3)

0.2

Central nervous system failure on D1

89 (23.9)

62 (17.5)

0.03

Number of organ failures during ICU stay

2.0 [2.0–3.0]

2.0 [2.0–3.0]

0.8

  0–1 organ failure

81 (21.8)

84 (23.7)

0.5

  2 organ failures

149 (40.1)

138 (39.0)

0.8

  3–4 organ failures

139 (37.4)

112 (31.6)

0.1

  5–6 organ failures

3 (0.8)

20 (5.6)

<0.001

Supportive treatments

  Mechanical ventilation

276 (74.2)

297 (83.9)

<0.001

  Sepsis corticosteroid

99 (27.0)

138 (40.0)

<0.001

  RRT

33 (8.9)

98 (27.7)

<0.001

  Maximum dose of norepinephrine during the first five days in the ICU (μg/kg/min)

0.18 [0.08–0.38]

0.25 [0.13–0.67]

<0.001

Received furosemide

262 (70.4)

285 (80.5)

0.002

  1. Values are expressed as count (%) and median [interquartile range]. AKI, acute kidney injury; KDIGO, Kidney Disease: Improving Global Outcomes; D1, first day in the ICU.