Table 1 Patient characteristics
From: Neurofilaments as a plasma biomarker for ICU-acquired weakness: an observational pilot study
ICU-AW (N:18) | no ICU-AW (N:59) | P-values | ||
|---|---|---|---|---|
Demographics | ||||
Men, number (%) | 10 (56) | 38 (64) | 0.58 | |
Age, mean year ± SD | 64 ± 15 | 60 ± 15 | 0.25 | |
Neurological co-morbidities | ||||
Risk factors for polyneuropathy, number (%) | 8 (44) | 28 (47) | 1 | |
Pre-existing polyneuropathy, number (%) | 2 (11) | 2 (3) | 0.23 | |
History of CNS disorder, number (%) | 3 (17) | 5 (8) | 0.38 | |
Any neurological co-morbidity, number (%)a | 12 (67) | 34 (57) | 0.59 | |
Admission characteristics | ||||
Admission type | ||||
Medical, number (%) | 12 (67) | 45 (76) | 0.54 | |
Surgical, number (%) | 6 (33) | 14 (24) | ||
LOS ICU, median days (IQR) | 15 (6 to 34) | 3 (1 to 6) | <0.01 | |
APACHE IV score, mean ± SD | 85 ± 25 | 68 ± 22 | 0.02 | |
Sepsis during admission, number (%) | 18 (100) | 45 (76) | 0.03 | |
Severe sepsis during admission, number (%) | 17 (94) | 30 (51) | <0.01 | |
Septic shock during admission, number (%) | 14 (78) | 15 (25) | <0.01 | |
MODS during admission, number (%) | 16 (89) | 30 (51) | 0.01 | |
CNS organ failure during admission, number (%) | 8 (44) | 4 (7) | <0.01 | |
Moment of muscle strength assessment, median day (IQR) | 8 (5 to 14) | 4 (2 to 6) | <0.01 | |
Average MRC score, median (IQR) | 2.8 (1.7 to 3.6) | 4.8 (4.2 to 5) | ||