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  • Meeting abstract
  • Open Access

Autoantibodies against oxidated low density lipoproteins (oLAb) and procalcitonin (PCT) as prognostic markers for patients suffering from sepsis and systemic inflammatory response syndrome (SIRS)

  • 1,
  • 1,
  • 1,
  • 1 and
  • 1
Critical Care19982 (Suppl 1) :P006

https://doi.org/10.1186/cc136

  • Published:

Keywords

  • Serum Level
  • Patient Group
  • Serum Sample
  • Emergency Medicine
  • Density Lipoprotein

Objective

To investigate the role of lipidperoxidation and infection during acute sepsis we measured antoantibodies against oxidated LDL (oLAb) and procalcitonin (PCT) comparing the neopterin as a marker of macrophages activation and CRP as marker of inflammation.

Design

A prospective, descriptive cohort study.

Patients

23 patients admitted to the ICU with verified sepsis (n=12, s=6) or SIRS (n=11, s = 6).

Measurements and results

The clinical severity of the disease was asessed using the APACHE II score over a period of 24 h after admission. Determination of serum levels of all parameters under study was performed on daily drawn serum samples. Surviving septic patients produced significantly increasing oLAbs (P < 0.001) as significantly decreasing PCT levels (P < 0.001). In contrast, in non-survivors oLAbs were decreasing (P < 0.05) and PCT levels were increasing (P < 0.05).

The identical effect was found for the SIRS group with the exception, that the significance of PCT in survivors was slightly lower (P < 0.05).

Conclusion

Despite both patient groups were rather small, we consider that the measurement of oLAb as well as PCT to be a useful prognostic marker concerning the outcome of sepsis as well as of SIRS patients.

Authors’ Affiliations

(1)
2nd Medical Department and Institute of Laboratory Medicine, General Hospital, St Veiterstraβ e 47, 9020 Klagenfurt, Austria

Copyright

© Current Science Ltd 1998

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