Skip to content


Critical Care

Open Access

Determining the mechanical ventilation mode and pressure support combination that is best compatible with the rapid shallow breathing index calculated in spontaneous ventilation

  • S Demirtas Yilmaz1,
  • G Gürsel1 and
  • M Aydogdu1
Critical Care201418(Suppl 1):P267

Published: 17 March 2014


Weaning from the mechanical ventilation (MV) composes about 40 to 50% of the total length of MV. Besides, there is no single reliable parameter indicating that patient will tolerate extubation safely. The rapid shallow breathing index (RSBI) is relatively the best predictive parameter for the initial assessment of readiness for discontinuation of MV support. But evaluation of the RSBI is valuable during T-tube ventilation; and in clinical practice it is not always possible to perform this assessment. In this study, we aimed to determine the best MV mode and pressure combinations that can predict successful RSBI closest to values calculated in spontaneous ventilation and estimate the patients' readiness for weaning.


In this prospective cohort study, 25 mechanically ventilated patients were included. After 24 hours of MV, if the patients can successfully pass the daily screening test a spontaneous breathing trial (SBT) was initiated. RSBI and other weaning parameters were calculated in different combinations (PS:5 PEEP:5, PS:0 PEEP:5, PS:5 PEEP:0, PS:0 PEEP:0) before T-tube trial in all patients. Measurements in the spontaneous ventilation was performed with the COSMOPLUS Novometrix device that has both capnography and respiratory monitorisation function; other measurements were performed with ventilators.


The mean age of the study group was 73 ± 10 years; 11 of them were female and mean APACHE II score was 19 ± 6. RSBI did not differ significantly between spontaneous mode and other combinations, but the best correlation with spontaneous mode was found with PS:5 PEEP:0 (P = 0.0001, r = 0.719), and the worst with PS:0 PEEP:5 combination. RSBI calculated in each combination showed no predictive value for weaning success. Respiration rate (f) was higher in the SBT failure group than the SBT success group. When measured at PS:0 PEEP:5 and PS:5 PEEP:0 combinations, the threshold value of f was found to be 27/minute (P = 0.03).


Although there was a correlation between RSBI measured in the T-tube and RSBI measured in different mode and pressure combinations, especially with the combination of PS:5 PEEP:0, a threshold value for RSBI cannot be detected during MV to predict SBT success.

Authors’ Affiliations

Gazi University Medical, Ankara, Turkey


© Demirtas Yilmaz et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.