Table 2 Plasma biomarkers at baseline (Day 0) in patients with sepsis

Global markers

  Platelet (× 10³/μL)

130 to 369

163 (118 to 205)

33.8^a

140 (108 to 184)

176 (136 to 228)

0.036

  PT-INR

0.9 to 1.2

1.25 (1.15 to 1.37)

55.8^b

1.29 (1.17 to 1.38)

1.21 (1.13 to 1.31)

0.091

  APTT (sec)

23.1 to 36.3

39.5 (32.2 to 48.9)

62.3^b

42.7 (35.4 to 49.5)

37.7 (31.3 to 42.7)

0.096

  Fibrinogen (mg/dL)

129 to 371

395 (249 to 544)

25.9^a

299 (225 to 481)

419 (319 to 565)

0.041

  FDP (μg/mL)

0 to 5.0

16.7 (10.4 to 28.9)

97.4^b

20.5 (11.7 to 44.1)

15.6 (8.4 to 22.1)

0.011

Thrombin generation

  TAT (ng/mL)

<2.4

12.5 (7.2 to 20.1)

98.7^b

19.5 (10.5 to 25.8)

8.4 (5.7 to 12.9)

<0.0001

  SF (μg/mL)

<7.0

10.5 (5.3 to 24.2)

66.2^b

13.9 (7.9 to 29.3)

7.4 (3.2 to 17.3)

0.013

Anticoagulant activity

  PC (%)

67 to 129

46.2 (34.1 to 59.5)

88.3^a

36.6 (28.1 to 44.9)

59.1 (46.7 to 65.6)

<0.0001

  AT (%)

75 to 125

51.8 (38.4 to 63.2)

88.3^a

42.8 (31.3 to 54.8)

58.2 (48.1 to 72.5)

0.0001

Fibrinolytic activity

  Plasminogen (%)

85 to 120

60.2 (43.6 to 73.7)

85.7^a

48.1 (30.3 to 66.1)

67.0 (57.1 to 84.6)

0.0001

  α2-PI (%)

83 to 115

67.3 (52.1 to 82.8)

74.1^a

54.1 (40.5 to 67.6)

78.6 (67.1 to 88.7)

<0.0001

  PAI-1 (ng/mL)

<50.0

154.7 (60.7 to 533.1)

81.8^b

531.6 (191.1 to 992.6)

77.6 (40.8 to 154.7)

<0.0001

  PIC (μg/mL)

<0.9

1.0 (0.7 to 1.8)

54.5^b

1.0 (0.6 to 2.7)

1.1 (0.8 to 1.5)

0.99

Endothelial activation

  sES (ng/mL)

<29.7

55.2 (35.9 to 101.1)

83.1^b

65.3 (34.8 to 144.8)

49.5 (36.9 to 72.9)

0.17