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Open Access

Terminal weaning from mechanical ventilation in critically ill patients with or without severe brain damage

  • R Parizkova1,
  • V Cerny1 and
  • P Dostal1
Critical Care20015(Suppl 1):P254

Received: 15 January 2001

Published: 2 March 2001


Public HealthMechanical VentilationEmergency MedicineBrain DamageDescriptive Study


The withdrawal of mechanical ventilation as a terminal care process occurs with increasing frequency. The aim of the study was to evaluate patients undergoing terminal weaning (TW) with or without severe brain damage.


A prospective, descriptive study of all patients experienced TW during 2 years period was conducted. Apache II, SOFA, length of ICU stay (days) before decision of TW (LOS), method (step-wise reduction or withdrawal of ventilatory support), using analgesia/sedation during TW procedure and length of TW (LTW) in minutes were recorded. Data as mean (SD), median (25-75%), t-test, Mann-Whitney Rank Sum Test (SigmaStat Statistical Software) were used, P < 0.05 was considered statistically significant.


Sixteen patients were studied, Apache II and SOFA score were 32 (6.9) resp. 12.9 (3.7). Eleven patients with severe brain damage (group BD), five patients without brain damage (group NBD). All patients died during TW. The LOS was shorter in BD group comparing to NBD group, 2.9 (1.9) resp. 17 (9.3), P < 0.0001. The TW procedure was step-wise reduction of ventilatory support in 5 patients and as a ventilator withdrawal in 11 patients. The length of TW was 17 (12-87) in BD group and 187 (16-605) in NBD group. Analgesia/sedation was employed in eight patients, there were no statistically significant differences in LTW between patients with or without analgesia/sedation (223, 13-662, resp. 15, 12-43, P = 0.232).


LOS before decision of TW was significantly longer in patients without brain damage. There were no significant differences in length of TW as between groups BD and NBD as between patients with or without analgesia.

Supported by IGA MZ CR 4530-3.

Authors’ Affiliations

Department of Anaesthetics and Intensive Care, Charles University, Hradec Kralove, Czech Republic


  1. Campbell LM, Bizek KS, Thill M: Patients responses during rapid terminal weaning from mechanical ventilation: a prospective study. Crit Care Med 1999, 27: 73-77. 10.1097/00003246-199901000-00029PubMedView ArticleGoogle Scholar


© The Author(s) 2001