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Figure 9 | Critical Care

Figure 9

From: Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis

Figure 9

Correlation of PD-1 expression and absolute cell counts and apoptosis. (A and B): Since anti-programmed cell death 1 (PD-1) antibody decreased lymphocyte apoptosis (Figure 4), we investigated the correlation between PD-1 expression on CD4 and CD8 T cells and absolute CD4 and CD8 T cells, respectively. Neither CD4 nor CD8 PD-1 expression correlated with absolute (total) CD4 or CD8 T cell counts respectively. (C): We also investigated the correlation between PD-1 expression and apoptosis by examining the relationship between percent PD-1 + CD4 T cells and the percent Tunel + CD4 T cells. At the time of the first blood draw in septic patients (days 1 to 3), there was a positive correlation between PD-1 expression on CD4 T cells and the percent of apoptotic cells (Tunel+).

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Critical Care

ISSN: 1364-8535