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Table 1 Clinical and SNP characteristics of non-survivors

From: Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis

Original diagnosis

Cause of death

Causative pathogen

BPI

LBP

TLR

HSP 70

IL-6

Risk variants of five genes

Crohn’s disease

Septic shock

CMV, Candida

A

A

A

B

A

H

Pneumonia

Septic shock

Not identified

A

A

A

B

A

H

Peritonitis

Septic shock

Not identified

A

A

A

A

B

H

Pneumonia

Severe sepsis

G + bacteria

A

B

A

A

B

I

Pneumonia

Septic shock

Not identified

A

A

A

A

B

H

Pneumonia

Septic shock

Not identified

A

B

A

A

A

H

Pneumonia

Septic shock

G- bacteria

A

A

A

A

B

H

Pneumonia

Severe sepsis

G + bacteria

A

B

A

B

B

I

Multiple injury

Septic shock

G + bacteria

A

A

A

A

B

H

Pneumonia

Septic shock

Not identified

A

A

A

B

A

H

Pneumonia

Severe sepsis

G- bacteria

A

A

A

B

A

H

Pneumonia

Septic shock

Not identified

A

A

A

A

A

I

Ileus

Septic shock

G + bacteria

A

A

A

A

B

H

Multiple injury

Sepsis

Not identified

A

A

A

A

B

H

Pneumonia

Severe sepsis

Not identified

B

A

A

B

B

I

Cranial injury

Septic shock

G + bacteria

A

A

A

A

B

H

Pneumonia

Septic shock

Aspergillus

A

B

A

B

B

I

Meningitis

Septic shock

Not identified

B

A

B

A

A

I

Pulm. embolism

Septic shock

Actinomyces

A

A

A

A

B

H

Pneumonia

Septic shock

G + bacteria

A

A

B

A

A

I

Pneumonia

Septic shock

Candida

A

B

B

A

B

I

Ileus

Septic shock

G- bacteria

A

B

A

A

B

I

Gastroenteritis

MODS

G- bacteria

A

A

A

A

B

H

  1. A, common (wild-type) homozygotes (aa); B, heterozygotes (ab) and minor homozygotes (bb); H, high-risk sepsis combination of five single nucleotide polymorphism (SNP) variants; I, intermediate risk sepsis combination of five SNP variants.