Time point (t) | Wild-type |
Tlr4
−/−
|
Rage
−/−
|
---|
t = 6 h | 239 (217 to 310) | 397 (221 to 535) | 526 (350 to 647) |
t = 24 h | 298 (250 to 380) | 236 (196 to 275) | 342 (262 to 404) |
t = 48 h | 429 (218 to 652) | 522 (421 to 756) | 395 (314 to 541) |
t = 72 h | 146 (99 to 190) | 90 (81 to 132) | 76 (47 to 104)* |
- Neutrophil numbers (×1000/ml) in bronchiolar lavage fluid at 6, 24, 48 and 72 hours after intranasal S. aureus infection in wild-type (Wt), Toll-like receptor (tlr)4−/− and Receptor for advanced glycation end products (Rage)−/− mice. Data are medians (interquartile ranges); n = 7 to 8 mice per group per time point. *P <0.05 versus Wt mice at the same time point.