Table 3 Univariable and multivariable regression analyses for factors associated with progression of AKI in patients with severe sepsis

CKD

4.696 (1.901, 11.600)

0.001

6.72 (2.19, 20.63)

0.001

7.24 (2.36, 22.23)

0.001

Diabetes mellitus

1.665 (1.041, 2.662)

0.033

NS

NS

Hypotension prior to ICU

1.883 (1.239, 2.863)

0.003

NS

NS

Radiocontrast dye prior to ICU

1.677 (1.056, 2.664)

0.029

NS

NS

Operative admission

1.685 (1.079, 2.631)

0.022

NS

NS

Abdominal infection

1.786 (1.117, 2.855)

0.015

NS

NS

SOFA D1 without renal point

1.136 (1.056, 1.223)

0.001

NS

NS

Use of sepsis corticosteroids

2.715 (1.715, 4.298)

<0.001

NS

NS

Use of dobutamine within first 24 h in the ICU

4.607 (2.259, 9.395)

<0.001

2.42 (1.00, 5.81)

0.049

2.68 (1.11, 6.48)

0.028

Norepinephrine max dose 24 h

4.234 (2.036, 8.803)

<0.001

NS

NS

Daily dose of furosemide (iv, mg)

1.006 (1.002, 1.009)

0.001

1.00 (1.00, 1.01)

0.002

1.01 (1.00, 1.01)

0.001

Fluid balance per hour on D1 in ICU

1.002 (1.000, 1.003)

0.005

NS

NS

Lactate 24 h highest

1.374 (1.218, 1.549)

<0.001

1.36 (1.18, 1.57)

<0.001

1.35 (1.17, 1.55)

<0.001

Time-adjusted MAP

0.952 (0.931, 0.973)

<0.001

0.96 (0.94, 0.99)

0.006

-

Time-adjusted MAP below 73 mmHg

2.440 (1.602, 3.716)

<0.001

-

2.57 (1.48, 4.46)

0.001