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Factors influencing the functional outcome in a neurointensive care unit


The aim of the present study was to investigate the factors that affect the outcome of patients with central nervous system pathology.


One hundred and thirty patients (head injury [n = 43], multiple trauma [n = 40], cerebral hemorrhage [n = 36] and emergency cerebral aneurysm repair [n = 11]) were investigated for age, GCS, CT-Scan grade, ISS, and APACHE II. Male to female ratio was 96/34. The patients were divided in five groups according to Glasgow Outcome Scale: 1) group A, n = 50 (GOS 1, death), 2) group B, n = 5 (GOS 2, severe brain damage), 3) group C, n = 17 (GOS 3, moderate brain damage), 4) group D, n = 28 (GOS 4, mild disability) and 5) group E, n = 30 (GOS 5, full recovery).


Total mortality was 38.4%. There was a statistically significant difference (one way analysis of variance ANOVA) regarding: 1) age: groups A, B and C versus E, 2) GCS: group A versus E, 3) CT-Scan grade: group A versus D and E, 4) ISS: group C versus D and E and 5) APACHE II score: group C versus E (Table). Patients with head injury or multiple trauma had better outcome than patients with cerebral hemorrhage (Fig.).

figure 1

Relation of diagnosis to GOS



Age, GCS and CT-Scan grade were related to the patient outcome regarding life or death whereas diagnosis, age, ISS and APACHE II determined the severity of disability.

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Anastasiou, E., Euthimiou, A., Lavrentieva, A. et al. Factors influencing the functional outcome in a neurointensive care unit. Crit Care 5, P246 (2001).

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  • Functional Outcome
  • Emergency Medicine
  • Head Injury
  • Brain Damage
  • Total Mortality