Skip to main content
Figure 5 | Critical Care

Figure 5

From: High fat feeding promotes obesity and renal inflammation and protects against post cardiopulmonary bypass acute kidney injury in swine

Figure 5

Survival signalling and apoptosis. (A) Pro-survival signalling; expressed as pAKt:Akt ratio and levels of downstream effectors. (B) Hypoxia inducible factor (HIF)-1 alpha. (C) p70S6K, a signalling protein in the Akt/mTOR pathway. (D) Apoptotic signalling as indicated by cleaved caspase 3 (CC3) levels, with values derived from densitometry of western blots and expressed as a ratio to β actin or glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Representative blots are shown. Values represent mean (standard error of the mean) of at least n = 4 per group. *P <0.05 versus sham, †P <0.05 versus Sham + HF, ‡P <0.05 versus CPB.

Back to article page

Critical Care

ISSN: 1364-8535