Early diagnosis of sepsis-related hepatic dysfunction and its prognostic impact on survival: a prospective study with the LiMAx test

Table 2 Impact of organ dysfunction on ICU LOS and mortality

Dysfunction	Definition	n (%)	LOS (days)^a	P value^b	Mortality (%)^a	P value^b
Cardiac	Low cardiac output requiring dobutamine	9 (32.1)	34 ± 24 vs. 33 ± 21	0.87	44.4 vs. 10.5	0.064
Hemodynamic	Hypotension requiring norepinephrine	22 (78.6)	37 ± 23 vs. 19 ± 10	0.067	27.3 vs. 0.0	0.20
Microcirculatory	Serum lactate >4.4 mmol/l	9 (32.1)	34 ± 24 vs. 32 ± 22	0.85	44.4 vs. 10.5	0.064
Hematologic	Platelet count <100/nl	11 (39.3)	40 ± 24 vs. 28 ± 20	0.18	27.3 vs. 17.6	0.44
Respiratory	Respiratory insufficiency requiring ventilation >24 hours	17 (60.7)	41 ± 24 vs. 21 ± 10	0.009	35.3 vs. 0.0	0.033
Renal injury	Serum creatinine >212 μmol/l or twofold increase	14 (50)	40 ± 26 vs. 27 ± 15	0.121	28.6 vs. 14.3	0.32
Failure	Serum creatinine >318 μmol/l or threefold increase	11 (39)	46 ± 25 vs. 25 ± 14	0.021	36.4 vs. 11.8	0.14
Hepatic	Bilirubin ≥70 μmol/l	6 (21.4)	47 ± 31 vs. 29 ± 17	0.24	33.3 vs. 18.2	0.38
	INR >1.5	15 (53.6)	40 ± 25 vs. 26 ± 14	0.09	26.7 vs. 15.4	0.40
	ICG-PDR ≤10.3%/minute	10 (35.7)	48 ± 21 vs. 25 ± 17	0.005	40.0 vs. 11.1	0.098
	LiMAx <100 μg/kg/hour	11 (39.3)	44 ± 19 vs. 26 ± 21	0.028	54.5 vs. 0.0	0.001

ICG-PDR, indocyanine green plasma disappearance rate; INR, International Normalised Ratio; LiMAx, maximal liver function capacity; LOS, length of stay after onset of sepsis. ^aPresence versus absence of organ failure. ^bIndependent t test. ^bFisher’s exact test.

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