Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome

Table 1 Demographic and clinical characteristics of 100 severe sepsis patients with ARDS (cases) and 100 severe sepsis patients without ARDS (controls)

Characteristic	ARDS casesnumber = 100	Controlsnumber = 100	P Value
Age	56 (51, 65)	59 (51, 65)	0.97
Male	52 (52%)	52 (52%)	1.0
Caucasian	89 (89%)	79 (79%)	0.10
Current smoker	35 (35%)	40 (40%)	0.56
APACHE II	28 (24, 32)	28 (24, 32)	1.0
Source of ICU admit
Emergency room	27 (27%)	37 (37%)	0.027
Hospital floor	40 (40%)	21 (21%)
Other hospital	23 (23%)	22 (22%)
Operating room	9 (9%)	17 (17%)
Other	1 (1%)	3 (3%)
Day of ALI onset
ICU day 1	91 (91%)	NA
ICU day 2	9 (9%)
Mechanical ventilation^a	83 (83%)	58 (58%)	<0.001
Any ventilatory support^b	89 (89%)	59 (59%)	<0.001
Non-pulmonary organ failure at enrollment	92 (92%)	91 (91%)	1.0
Vasopressors at enrollment	44 (44%)	43 (43%)	0.50
ICU stay (days)	9 (5, 13)	5 (3, 11)	0.003
Ventilator-free days	18 (2, 24)	25 (7, 28)	<0.001
Hospital mortality	29 (29%)	27 (27%)	0.87

Data as median (1^st and 3^rd quartiles) or Number (%) as indicated. NA = not applicable. ^aMechanical ventilation on any study day; ^bmechanical ventilation or noninvasive ventilation on any study day. ALI, acute lung injury; APACHE II, Acute Physiology and Chronic Health Evaluation II; ARDS, acute respiratory distress syndrome.

ISSN: 1364-8535