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Table 3 Performance of multivariable models for predicting severe sepsis, septic shock and 28-day mortality in septic patients

From: Diagnostic value and prognostic evaluation of Presepsin for sepsis in an emergency department

  Variable Cutoff Sensitivity (%) Specificity (%) PPV (%) NPV (%) Accuracy (%) LR+ LR–
Severe sepsis Presepsin 449 pg/ml 82.4 72.4 71.3 83.2 77.0 2.99 0.24
  Procalcitonin 1.435 ng/ml 52.0 79.8 69.6 65.1 66.7 2.57 0.60
  MEDS score 13.5 score 63.0 86.3 79.2 73.8 75.8 4.60 0.42
  APACHE II score 16.5 score 69.8 68.5 64.8 73.3 69.1 2.22 0.44
Septic shock Presepsin 550 pg/ml 85.7 63.6 28.5 96.3 66.8 2.35 0.22
  Procalcitonin 4.415 ng/ml 54.1 81.1 34.2 90.7 77.0 2.86 0.57
  MEDS score 16.5 score 75.5 90.0 56.1 95.6 87.9 7.55 0.27
  APACHE II score 20.5 score 70.4 78.4 35.4 94.0 77.2 3.26 0.38
28-day mortality Presepsin 556 pg/ml 62.2 66.8 48.3 78.0 65.3 1.87 0.57
  Procalcitonin 1.125 ng/ml 54.2 70.0 47.7 75.1 64.7 1.81 0.65
  MEDS score 13.5 score 59.1 75.4 54.3 78.9 70.0 2.40 0.54
  APACHE II score 16.5 score 71.1 62.2 48.2 81.3 65.1 1.88 0.46
  1. APACHE, Acute Physiology and Chronic Health Evaluation; LR+, positive likelihood ratio, LR–, negative likelihood ratio; MEDS, Mortality in Emergency Department Sepsis; NPV, negative predictive value; PPV, positive predictive value.