Table 3 Performance of multivariable models for predicting severe sepsis, septic shock and 28-day mortality in septic patients
From: Diagnostic value and prognostic evaluation of Presepsin for sepsis in an emergency department
Variable | Cutoff | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | LR+ | LR– | |
|---|---|---|---|---|---|---|---|---|---|
Severe sepsis | Presepsin | 449 pg/ml | 82.4 | 72.4 | 71.3 | 83.2 | 77.0 | 2.99 | 0.24 |
Procalcitonin | 1.435 ng/ml | 52.0 | 79.8 | 69.6 | 65.1 | 66.7 | 2.57 | 0.60 | |
MEDS score | 13.5 score | 63.0 | 86.3 | 79.2 | 73.8 | 75.8 | 4.60 | 0.42 | |
APACHE II score | 16.5 score | 69.8 | 68.5 | 64.8 | 73.3 | 69.1 | 2.22 | 0.44 | |
Septic shock | Presepsin | 550 pg/ml | 85.7 | 63.6 | 28.5 | 96.3 | 66.8 | 2.35 | 0.22 |
Procalcitonin | 4.415 ng/ml | 54.1 | 81.1 | 34.2 | 90.7 | 77.0 | 2.86 | 0.57 | |
MEDS score | 16.5 score | 75.5 | 90.0 | 56.1 | 95.6 | 87.9 | 7.55 | 0.27 | |
APACHE II score | 20.5 score | 70.4 | 78.4 | 35.4 | 94.0 | 77.2 | 3.26 | 0.38 | |
28-day mortality | Presepsin | 556 pg/ml | 62.2 | 66.8 | 48.3 | 78.0 | 65.3 | 1.87 | 0.57 |
Procalcitonin | 1.125 ng/ml | 54.2 | 70.0 | 47.7 | 75.1 | 64.7 | 1.81 | 0.65 | |
MEDS score | 13.5 score | 59.1 | 75.4 | 54.3 | 78.9 | 70.0 | 2.40 | 0.54 | |
APACHE II score | 16.5 score | 71.1 | 62.2 | 48.2 | 81.3 | 65.1 | 1.88 | 0.46 |