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Figure 4 | Critical Care

Figure 4

From: Stress-dose hydrocortisone reduces critical illness-related corticosteroid insufficiency associated with severe traumatic brain injury in rats

Figure 4

Stress-dose hydrocortisone increases corticosteroid response after traumatic brain injury. Corticosterone increase index (CII) of rats treated with stress-dose hydrocortisone (HC) was significantly higher than that of those from the injury control group or those treated with low-dose methylprednisolone (MP) on day 7 post-injury. Data are expressed as mean ± standard error of the mean. (#P <0.001 as compared to HC normal treatment; *P = 0.005 as compared to injury control; çP = 0.022 as compared to low-dose MP). Pre-injury: n = 30 from each group; day 3: n = 30 from HC normal, n = 23 from injury control, n = 23 from low-dose MP, n = 26 from stress-dose HC; day 7: n = 30 from HC normal, n = 16 from injury control, n = 15 from low-dose MP, n = 22 from stress-dose HC; day 14: n = 30 from HC normal, n = 8 from injury control, n = 10 from low-dose MP, n = 17 from stress-dose HC.

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Critical Care

ISSN: 1364-8535