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Table 1 Demographic, clinical, laboratory and markers data

From: Pro-adrenomedullin, pro-endothelin-1, procalcitonin, C-reactive protein and mortality risk in critically ill children: a prospective study

Demographic and clinical characteristics

Group A (n = 33)

Group B (n = 221)

P-value

Overall population N = 254

Age at admission (months)

19 (50)

45 (99)

0.012

44 (81)

Weight (kg)

11.0 (10.5)

16.0 (22.0)

0.005

15.0 (17.4)

Male sex (%)

60,6

58,8

0,853

59,1

Admission diagnosis

Group A (n = 33)

Group B (n = 221)

P -value

Overall population N = 254

Postoperative

1 (1.7)

59 (98.7)

<0.001

60 (23.6)

Cardiac surgery

21 (44.7)

26 (55.3)

0.560

47 (18.5)

Respiratory

1 (2.2)

44 (97.8)

<0.001

45 (17.7)

Infectious

5 (12.5)

35 (87.5)

<0.001

40 (15.7)

Traumatic

2 (11.8)

15 (88.2)

0.002

17 (6.7)

Neurologic

10 (100)

0 (0)

-

10 (3.9)

Metabolic-Renal

1 (11.1)

8 (88.9)

0.039

9 (3.6)

Others

2 (7.7)

24 (92.3)

<0.001

26 (16.8)

PRISM III (absolute value)

13.0 (7.5)

2.0 (5.0)

<0.001

3.0 (8.0)

PIM 2 (%)

4.2 (6.7)

0.8 (1.0)

<0.001

0.9 (1.73)

Laboratory data

Group A (n = 33)

Group B (n = 221)

P -value

Overall population N = 254

pH

7.26 (0.16)

7.35 (0.10)

0.001

7.34 (0.10)

Bicarbonate (mEq/L)

16.8 (8.9)

21.9 (3.9)

0.030

21.8 (3.9)

Lactate (mmol/L)

1.20 (1.13)

0.90 (1.10)

0.027

1.00 (1.10)

Platelets (X1000/mm3)

228.5 (240.4)

289.0 (169.0)

0.043

281.0 (168.0)

Markers

Group A (n = 33)

Group B (n = 221)

P -value

Overall population N = 254

CRP (mg/dl)

6.23 (15.5)

1.30 (8.8)

0.210

1.47 (10.1)

PCT (ng/ml)

7.76 (25.81)

0.27 (1.36)

<0.001

0.34 (1.83)

MR-proADM (nmol/l)

1.39 (1.59)

0.53 (0.41)

<0.001

0.58 (0.39)

CT-proET-1 (pmol/l)

172.3 (82.70)

58.47 (56.50)

<0.001

67.59 (53.13)

Markers

Group A1 (n = 71)

Group B1 (n = 182)

P -value

Overall population N = 253

CRP (mg/dl)

9.57 (15.4)

1.07 (7.5)

<0.001

1.47 (10.1)

PCT (ng/ml)

4.91 (32.7)

0.20 (1.28)

<0.001

0.34 (1.83)

MR-proADM (nmol/l)

1.380 (1.60)

0.471 (0.28)

<0.001

0.58 (0.39)

CT-proET-1 (pmol/l)

159.09 (97.40)

52.65 (41.00)

<0.001

67.59 (53.13)

  1. Group A: Higher score risk mortality group. Group B: Lower score risk mortality group; Group A1: number of organ failures >1. Group A2: number of organ failures <2; admission diagnosis is described by the absolute and relative values (%); the rest of the variables are described by median and interquartile range. CRP: C-reactive protein; CT-pro-ET1: C-terminal-pro-endothelin-1; PCT:procalcitonin; MR-pro-ADM: midregional-pro-adrenomedullin.
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