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Table 1 Patient characteristics in quartiles according to oldest red blood cell (RBC) transfusion during the ICU stay

From: Age of red blood cells and outcome in acute kidney injury

  Q1 Q2 Q3 Q4 P-value
(n = 143) (n = 156) (n = 179) (n = 174)
Age, years 66 (58, 76) 66 (57, 75) 65 (54, 74) 66 (55, 75) 0.686
Male gender 82 (57.3%) 102 (65.4%) 114 (63.7%) 113 (64.9%)  
Operative admission 80 (55.9%) 85 (54.5%) 92 (51.4%) 74 (42.5%) 0.067
Emergency admission, n/total 105/143 (73.4%) 114/153 (74.5%) 146/174 (83.9%) 149/172 (85.6%) 0.004
Emergency surgery <1 week 38 (26.6%) 42 (26.9%) 58 (32.45) 49 (28.2%) 0.369
Cardiac or vascular surgery 44 (30.8%) 56 (35.9%) 41 (22.9%) 29 (16.7%) <0.001
Trauma 9 (6.3%) 6 (3.8%) 16 (8.9%) 13 (7.5%) 0.303
Severe sepsis 34 (23.8%) 50 (32.1%) 69 (38.5%) 69 (39.7%) 0.011
DIC 5/140 (3.5%) 12/151 (7.9%) 13/170 (7.6%) 16/168 (9.5%) 0.239
Acute kidney injury 52 (36.4%) 78 (50.0%) 69 (38.5%) 69 (39.7%) 0.029
Renal replacement therapy 8 (5.6%) 28 (17.9%) 34 (19.0%) 26 (14.9%) 0.004
SAPS II score 35 (27, 44) 36 (30, 50) 40 (28, 55) 38 (31, 53) 0.050
Maximum SOFA score 8 (6, 10) 9 (6, 11) 9 (6, 11) 9 (6, 11)a 0.031
Mechanical ventilaiton 110 (76.9%) 132 (84.6%) 149 (83.2%) 132 (75.9%) 0.112
Vasoactive use 111 (77.6%) 124 (79.5%) 142 (79.3%) 130 (74.7%)a 0.751
Lactate, mmol/Lb 1.96 (1.20, 3.40) 2.80 (1.50, 3.40) 2.40 (1.44, 4.60) 2.54 (1.50, 4.77) 0.009
Age of all RBCs, days 11 (9, 12) 14 (11, 15) 17 (13, 20) 17 (12, 26) <0.001
Maximum age of RBCs, days 12 (10, 13) 15 (14, 16) 21 (19, 22) 29 (27, 32) <0.001
Transfused units, n 2 (2, 4) 3 (2, 5) 3 (2, 6) 4 (2, 8) 0.001
RBC units over 14 days old, n 0 2 (1, 3) 2 (1, 4) 3 (2, 6) <0.001
Massive transfusion pre-ICUc 8 (5.6%) 9 (5.8%) 7 (3.9%) 15 (8.6%) 0.312
Admission hemoglobin, g/L d 100 (90, 112) 97 (88, 107) 97(88, 110)] 98 (85, 113) 0.544
  1. Results are presented as median (IQR) or number (%). aData missing for 1 patient in Q4; bhighest lactate 24 h preceding ICU admission or on first ICU treatment day, data missing for 11 patients in Q1 and Q2, in 12 patients in Q3, and 17 patients in Q4 (and 40 patients in Q2 to Q4); ctransfusion >10 RBC units in 24 hours; ddata missing for 11 patients in Q1, 19 in Q2, 27 in Q3, 20 in Q4 (and 86 patients in Q2-4); n, number; RBC, red blood cell; DIC, disseminated intravascular coagulopathy; SAPS II, simplified acute physiology score; SOFA, sequential organ failure assessment.