Skip to main content

Volume 17 Supplement 4

Sepsis 2013

Is Strongyloides stercoralis a risk factor for sepsis severity?


Sepsis is a complex disease with an initial proinflammatory profile triggered by an infection process, which is typically followed by a compensatory anti-inflammatory response, leading to immunosuppression. There are few cases in literature relating sepsis with opportunistic infections, such as strongyloidiasis, which may lead to severe clinical consequences due to hyperinfection. Human strongyloidiasis is a neglected tropical disease of major worldwide distribution, affecting millions of people. Despite of the fact that infection with Strongyloides stercoralis is usually self-limited and with low morbidity in immunocompetent individuals, it may become lethal in cases of immunosuppression, such as AIDS, corticosteroid treatment and transplantation. Our aim in this work was to investigate the presence of S. stercoralis antigens and anti-parasitic IgG in sepsis patients in a highly endemic area of strongyloidiasis.

Materials and methods

Serum samples from 27 individuals with strongyloidiasis and 27 healthy subjects were used as positive and negative controls, respectively, according to their parasitological analyses. Additionally, 27 sepsis patients were also investigated. We have used ELISA tests to detect S. stercoralis antigens and IgG anti-S. stercoralis in all three groups. The cutoff value was determined by the ROC curves obtained by Prism 5.0 software.


IgG anti-S. stercoralis was detected in six patients; five under septic shock and one with sepsis. Among them, four were positive for the parasite antigen-antibody immune complex; three under septic shock and one with sepsis, demonstrating that 15% of sepsis patients were infected by the parasite, which may have significantly contributed with the hyperinfection presented by septic-shock patients (10%).


There are only two reports of an association between S. stercoralis infection and immunosuppression, which led to lethal sepsis cases. However, our preliminary analysis through antigen-antibody immune complex demonstrated that this parasitic infection might be more common in sepsis than expected. The correct diagnosis of the causal infection in sepsis may support the correct therapeutic choice, which is fundamental to avoid the continuous spread of specific pathogen/parasite triggers that will eventually lead to hyperinfection, and consequently to severe sepsis.


The authors would like to thank the patients and their families for the direct collaboration in this work, the medical staff from the ICU of the university hospital for providing the biological samples and the clinical parameters, and financial support by CNPq, CAPES, and FAPEMIG.

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Alves, P.T., Levenhagen, M.A., Santos, F.d.A.A. et al. Is Strongyloides stercoralis a risk factor for sepsis severity?. Crit Care 17 (Suppl 4), P16 (2013).

Download citation

  • Published:

  • DOI:


  • Septic Shock
  • Sepsis Severity
  • ELISA Test
  • Tropical Disease
  • Sepsis Patient