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Table 4 Settings, delivered ventilation, respiratory mechanics and blood gas results according to the lung condition in passive patients

From: Feasibility study on full closed-loop control ventilation (IntelliVent-ASV) in ICU patients with acute respiratory failure: a prospective observational comparative study

  1 Normal lung 2 ARDS 3 COPD 4 Others P (ANOVA) Post hoc comparison (P ≤ 0.05)
Number of patients 27 13 12 15   
Number of days 63 36 23 40   
MV (L/min) 8.4 (6.73-9.7) 7.9 (6.1-8.8) 7.8 (5.3-9.0) 7.2 (5.3-8.5) 0.076  
VT/PBW (mL/kg) 8.1 (7.3-8.9) 7.5 (6.9-7.9) 9.9 (8.3-11.1) 8.0 (7.5-9.2) <0.001 1 vs. 2; 1 vs. 3; 2 vs. 3; 2 vs. 4
PEEP (cmH2O) 5 (5-6) 11 (8-13) 8 (5-15) 10 (5-13) <0.001 1 vs. 2; 1 vs. 3; 1 vs. 4
FiO2 (%) 30 (30-31) 35 (33-47) 31 (30-38) 31 (30-53) <0.001 1 vs. 2; 1 vs. 4
PINSP (cmH2O) 21 (19-23) 27 (24-30) 27 (23-39) 26 (23-30) <0.001 1 vs. 2; 1 vs. 3; 1 vs. 4
RR (breath/min) 17 (15-21) 16 (15-20) 13 (12-15) 15 (13-18) <0.001 1 vs. 3; 1 vs. 4; 2 vs. 3
RCEXP (s) 0.58 (0.50-0.72) 0.47 (0.40-0.54) 1.22 (0.68-1.37) 0.57 (0.46-0.72) <0.001 1 vs. 2; 1 vs. 3; 2 vs. 3; 2 vs. 4; 3 vs. 4
RINSP (cm H2O/s/L) 15 (12-17) 11 (10-16) 21 (17-26) 16 (12-20) <0.001 1 vs. 3; 2 vs. 3; 2 vs. 4
CSTAT (L/cm H2O) 39 (35-54) 29 (26-37) 53 (46-61) 32 (28-40) <0.001 1 vs. 2; 1 vs. 4; 2 vs. 3; 3 vs. 4
I/E ratio 0.61 (0.43-0.77) 0.91 (0.83-1.00) 0.43 (0.32-0.50) 0.77 (0.61-1.00) <0.001 1 vs. 2; 2 vs. 3; 3 vs. 4
PPLAT (cm H2O) 18 (17-20) 26 (23-29) 23 (17-31) 24 (21-28) <0.001 1 vs. 2; 1 vs. 3; 1 vs. 4
PaO2/FiO2 (mm Hg) 328 (264-366) 201 (155-256) 253 (206-295) 208 (147-301) <0.001 1 vs. 2; 1 vs. 3; 1 vs. 4
PaO2 (mm Hg) 99 (85-114) 74 (66-88) 83 (77-94) 82 (70-95) <0.001 1 vs. 2; 1 vs. 4
pH 7.33 (7.27-7.40) 7.24 (7.15-7.34) 7.29 (7.20-7.31) 7.29 (7.22-7.34) 0.002 1 vs. 2; 1 vs. 3
PaCO2 (mm Hg) 38 (35-42) 49 (45-57) 49 (44-67) 43 (38-51) <0.001 1 vs. 2; 1 vs. 3; 1 vs. 4; 2 vs. 4; 3 vs. 4
  1. Values represent the median of all data. Comparisons used a Kruskal-Wallis analysis of variance (ANOVA) with a Dunn's post hoc test. MV, minute volume, VT/PBW, tidal volume on predicted body weight ratio, PEEP, positive end-expiratory pressure, PINSP, peak inspiratory pressure, RR, respiratory rate, RCEXP, expiratory time constant, RINSP, inspiratory resistances, CSTAT, static compliance, I/E, inspiratory on expiratory time ratio, PPLAT, plateau pressure, vs., versus.