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Table 4 Settings, delivered ventilation, respiratory mechanics and blood gas results according to the lung condition in passive patients

From: Feasibility study on full closed-loop control ventilation (IntelliVent-ASV™) in ICU patients with acute respiratory failure: a prospective observational comparative study

 

1

Normal lung

2

ARDS

3

COPD

4

Others

P (ANOVA)

Post hoc comparison (P ≤ 0.05)

Number of patients

27

13

12

15

  

Number of days

63

36

23

40

  

MV (L/min)

8.4 (6.73-9.7)

7.9 (6.1-8.8)

7.8 (5.3-9.0)

7.2 (5.3-8.5)

0.076

 

VT/PBW (mL/kg)

8.1 (7.3-8.9)

7.5 (6.9-7.9)

9.9 (8.3-11.1)

8.0 (7.5-9.2)

<0.001

1 vs. 2; 1 vs. 3; 2 vs. 3; 2 vs. 4

PEEP (cmH2O)

5 (5-6)

11 (8-13)

8 (5-15)

10 (5-13)

<0.001

1 vs. 2; 1 vs. 3; 1 vs. 4

FiO2 (%)

30 (30-31)

35 (33-47)

31 (30-38)

31 (30-53)

<0.001

1 vs. 2; 1 vs. 4

PINSP (cmH2O)

21 (19-23)

27 (24-30)

27 (23-39)

26 (23-30)

<0.001

1 vs. 2; 1 vs. 3; 1 vs. 4

RR (breath/min)

17 (15-21)

16 (15-20)

13 (12-15)

15 (13-18)

<0.001

1 vs. 3; 1 vs. 4; 2 vs. 3

RCEXP (s)

0.58 (0.50-0.72)

0.47 (0.40-0.54)

1.22 (0.68-1.37)

0.57 (0.46-0.72)

<0.001

1 vs. 2; 1 vs. 3; 2 vs. 3; 2 vs. 4; 3 vs. 4

RINSP (cm H2O/s/L)

15 (12-17)

11 (10-16)

21 (17-26)

16 (12-20)

<0.001

1 vs. 3; 2 vs. 3; 2 vs. 4

CSTAT (L/cm H2O)

39 (35-54)

29 (26-37)

53 (46-61)

32 (28-40)

<0.001

1 vs. 2; 1 vs. 4; 2 vs. 3; 3 vs. 4

I/E ratio

0.61 (0.43-0.77)

0.91 (0.83-1.00)

0.43 (0.32-0.50)

0.77 (0.61-1.00)

<0.001

1 vs. 2; 2 vs. 3; 3 vs. 4

PPLAT (cm H2O)

18 (17-20)

26 (23-29)

23 (17-31)

24 (21-28)

<0.001

1 vs. 2; 1 vs. 3; 1 vs. 4

PaO2/FiO2 (mm Hg)

328 (264-366)

201 (155-256)

253 (206-295)

208 (147-301)

<0.001

1 vs. 2; 1 vs. 3; 1 vs. 4

PaO2 (mm Hg)

99 (85-114)

74 (66-88)

83 (77-94)

82 (70-95)

<0.001

1 vs. 2; 1 vs. 4

pH

7.33 (7.27-7.40)

7.24 (7.15-7.34)

7.29 (7.20-7.31)

7.29 (7.22-7.34)

0.002

1 vs. 2; 1 vs. 3

PaCO2 (mm Hg)

38 (35-42)

49 (45-57)

49 (44-67)

43 (38-51)

<0.001

1 vs. 2; 1 vs. 3; 1 vs. 4; 2 vs. 4; 3 vs. 4

  1. Values represent the median of all data. Comparisons used a Kruskal-Wallis analysis of variance (ANOVA) with a Dunn's post hoc test. MV, minute volume, VT/PBW, tidal volume on predicted body weight ratio, PEEP, positive end-expiratory pressure, PINSP, peak inspiratory pressure, RR, respiratory rate, RCEXP, expiratory time constant, RINSP, inspiratory resistances, CSTAT, static compliance, I/E, inspiratory on expiratory time ratio, PPLAT, plateau pressure, vs., versus.
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