Patients with sepsis exhibit increased mitochondrial respiratory capacity in peripheral blood immune cells

Table 2 Clinical characteristics of patients and controls at time of blood sampling

	Day of sample 1	Day of sample 2	Day of sample 3	Controls
SOFA	8.0 (6.5-11)	7.0 (3–10)	6.5 (4.8-9.8)	-
Noradrenaline	0.13 (0.045-0.52)	0.0 (0.0-0.08)	0.0 (0.0-0.09)	-
Dobutamine	4.7 (2.9-9.1)	2.0 (1.0-10)	-	-
IL-6	259 (112–1433)^a	51 (30–80)^a	26 (18–65)^a	1.2 (1.0–2.3)
TNF-α	26 (10–44)^a	11 (8.9-20)^a	6.7 (5.2-8.7)^b	3.7 (2.7-4.2)
IL-1β	2.1 (1.2-3.5)^a	0.9 (0.6-1.3)	0.9 (0.7-1.2)	0.5 (0.2-0.6)

Data presented as median (IQR). SOFA, Sequential Organ Failure Assessment. Inotropic drugs are expressed as μg/kg/min, and cytokine levels as pg/ml. Patients receiving noradrenaline: sample 1, n = 19; sample 2, n = 6; sample 3, n = 3. Dobutamine: sample 1, n = 4; sample 2, n = 3; sample 3, n = 0. ^aP < 0.001; ^bP < 0.05, compared with controls.

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