Figure 1
From: High positive end-expiratory pressure: only a dam against oedema formation?
Study design. Initial lung weights were measured by CT. Animals were then ventilated with high PEEP (volume of gas around 75% of IC; dotted line) and low VT (25% of IC; spikes) for 36 h (PEEP phase). Thereafter, PEEP was suddenly zeroed and low VT maintained for 18 additional h (ZEEP phase). Animals were then sacrificed and final lung weights were measured on a balance. B, baseline; CT, computed tomography; FRC, functional residual capacity; IC, inspiratory capacity; PEEP, positive end-expiratory pressure; TLC, total lung capacity; VT, tidal volume; ZEEP, zero end-expiratory pressure..