Skip to main content

Table 1 Ventilation pressures and arterial blood gases at Baseline and at 150 and 300 min (median and range).

From: Mechanical ventilation worsens abdominal edema and inflammation in porcine endotoxemia

  Study group Baseline All healthy 150 minutes Healthy/LPS Change to ventilation 300 minutes Healthy/LPS
P aw max
cm H 2 O
PEEP 5 Healthy 18.5; 17-21 18.7; 17-22   21.2; 18-26
     CPAP 5 LPS 9.0; 8-10
  PEEP 5 LPS 20.1; 17-23 25.3; 18-35 PEEP 5 LPS 26.5; 25-324
     PEEP 15 LPS 34.0; 32-374,5
P aw mean SB Healthy 2,0; 2.0-2.0 1.5; 1.0-3.0   1.0; 1.0-2.0
cm H 2 O PEEP 5 Healthy 9.0; 8.0-10.01 9.0; 8.0-10.0   9.0; 8.0-10.01
     CPAP 5 LPS 6.0; 5.0-6.0
  PEEP 5 LPS 8.3; 8.0-9.0 9.8; 9-11 PEEP 5 LPS 10; 9.0-11.04
     PEEP 15 LPS 19.5; 19.0-20.0,4,5
PaO 2 SB Healthy 25.5; 22.2-27.2 25.3; 20.5-30.6   22.7; 15.1-25.9
mm Hg PEEP 5 Healthy 37.7; 31.0-39.21 32.8; 29.8-36.8   32.5; 28.3-34.41
     CPAP 5 LPS 13.5; 8.2-39.5
  PEEP 5 LPS 33.1; 24.3-37.0 24.3; 6.9-36.52 PEEP 5 LPS 25.4; 8.7-32.1
     PEEP 15 LPS 32.3; 26.4-34.4*
PaCO 2 SB Healthy 5.5; 4.7-5.9 5.0; 4.7-5.3   5.0; 4.5-5.2
mm Hg PEEP 5 Healthy 4.9; 4.1-5.31 4.8; 4.4-5.3   4.9; 4.4-5.3
     CPAP 5 LPS 6.7; 6.2-8.73
  PEEP 5 LPS 4.7; 3.7-5.2 5.7; 4.4-6.62 PEEP 5 LPS 5.5; 4.5-6.64
     PEEP 15 LPS 5.1; 4.5-6.44
  1. (Peak airway pressure was not recorded in the healthy, spontaneously breathing pigs.) Note that the pigs given endotoxin (LPS) were all ventilated with PEEP 5 for the first 150 minutes (2.5 hours) and then either maintained on MV + PEEP 5 or switched to MV + PEEP 15 or SB + CPAP 5 for the next 2.5 hours (until 300 minutes); n = 6 in all groups. Significances (P < 0.05) after correction for multiple comparisons (Bonferroni):
  2. Comparison with:
  3. 1: SB Healthy
  4. 2: Baseline
  5. 3: 150 minutes
  6. 4: CPAP 5 LPS
  7. 5: PEEP 5 LPS
  8. *: indicates difference of borderline significance between MV+PEEP 15 and CPAP 5 (0.05 <P < 0.10; correction for multiple comparisons).