Figure 3

Receiver operating characteristic (ROC) curve analysis of percentages of CD19+CD23+, CD19+CD80+ and CD19+CD95+ for predicting the risk of death at ICU admission. For CD19+CD23+, a cut-off value of 64% showed sensitivity of 90.9% (95% confidence interval (CI) = 75.6% to 98.0%) and specificity of 80.0% (95% CI = 61.4% to 92.0%) for predicting the risk of death, with a positive predictive value of 89.4%, a negative predictive value of 82.7% and area under the ROC curve 0.818 ± 0.055 (95% CI = 0.701 to 0.904; P = 0.0001). For CD19+CD80+ and CD19+CD95+, respectively, cut-off values of 20% and 17% showed sensitivity of 81.8% (95% CI = 64.5% to 92.8%) and 81.9% (95% CI = 64.2% to 93.0%) and specificity of 70% (95% CI = 50.6% to 85.2%) and 75% (95% CI = 53.3% to 90.2%) for predicting the risk of death on day 28, with the area under the ROC curve 0.751 ± 0.061 (95% CI = 0.630 to 0.854) and 0.795 ± 0.058 (95% CI = 0.668 to 0.891) (P = 0.0001 for both).