The 372 T/C genetic polymorphism of TIMP-1 is associated with serum levels of TIMP-1 and survival in patients with severe sepsis

Table 3 Multiple logistic regression analysis to predict 30-day mortality.

	Odds ratio	95% confidence interval	P value
First model including all patients
Lactic acid	1.19	1.07 to 1.32	0.001
APACHE II	1.08	1.04 to 1.13	<0.001
Gender female	1.26	0.68 to 2.33	0.46
Presence of T allele^a	2.08	1.06 to 4.09	0.03
Second model including only women
Lactic acid	1.18	1.02 to 1.36	0.03
APACHE II	1.10	1.02 to 1.18	0.009
Presence of T allele^a	1.45	0.57 to 3.64	0.43
Third model including only men
Lactic acid	1.21	1.04 to 1.40	0.01
APACHE II	1.08	1.02 to 1.13	0.008
Presence of T allele^a	1.44	1.002 to 2.072	0.049
Four model including all patients
Lactic acid	1.13	1.02 to 1.27	0.03
APACHE II	1.08	1.03 to 1.13	<0.001
TIMP-1 levels	1.001	1.0002 to 1.002	0.008
Five model including only women
Lactic acid	1.13	0.95 to 1.34	0.16
APACHE II	1.14	1.04 to 1.24	0.003
TIMP-1 levels	1.001	1.0002 to 1.003	0.048
Six model including only men
Lactic acid	1.13	1.06 to 1.62	0.01
APACHE II	1.10	1.02 to 1.19	0.02
TIMP-1 levels	1.0001	0.999 to 1.001	0.48

APACHE, Acute Physiology and Chronic Health Evaluation; TIMP, tissue inhibitor of matrix metalloproteinase. ^aT allele of the 372 T/C genetic polymorphism of TIMP-1.

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