Total population (n= 67,717) | Eligible for RCT (n= 27,392) | Non-eligible for RCT (n= 40,325) | P value | |
---|---|---|---|---|
Age, years | 64 (50 to 75) | 58.2 (46 to 68) | 69 (53 to 79) | <0.0001 |
Gender, male | 42,977 (63%) | 18,177 (66%) | 24,800 (62%) | <0.0001 |
Charlson Index ≥2 | 8,366 (12%) | 1,254 (5%) | 7,112 (18%) | <0.0001 |
Referred from ED | 28,847 (42%) | 12,730 (46%) | 16,117 (40%) | <0.0001 |
SAPS 2 | 46 (34 to 63) | 38 (25 to 53) | 49 (36 to 66) | <0.0001 |
Mechanical ventilation | 52,783 (78%) | 21,290 (78%) | 31,493 (78%) | 0.249 |
Renal replacement therapy | 12,654 (19%) | 3,429 (13%) | 9,225 (23%) | <0.0001 |
Vasopressors | 40,126 (59%) | 14,211 (52%) | 25,915 (64%) | <0.0001 |
ICU mortality | 22,970 (34%) | 6,613 (24%) | 16,357 (41%) | <0.0001 |
In-hospital mortality | 22,447 (33%) | 6,088 (22%) | 16,359 (41%) | <0.0001 |