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Table 3 Characteristics and eligibility/non-eligibility distribution of severe sepsis and septic shock patients from Cub-Rea

From: Are clinical trials dealing with severe infection fitting routine practices? Insights from a large registry

 

Total population (n= 67,717)

Eligible for RCT (n= 27,392)

Non-eligible for RCT (n= 40,325)

P value

Age, years

64 (50 to 75)

58.2 (46 to 68)

69 (53 to 79)

<0.0001

Gender, male

42,977 (63%)

18,177 (66%)

24,800 (62%)

<0.0001

Charlson Index ≥2

8,366 (12%)

1,254 (5%)

7,112 (18%)

<0.0001

Referred from ED

28,847 (42%)

12,730 (46%)

16,117 (40%)

<0.0001

SAPS 2

46 (34 to 63)

38 (25 to 53)

49 (36 to 66)

<0.0001

Mechanical ventilation

52,783 (78%)

21,290 (78%)

31,493 (78%)

0.249

Renal replacement therapy

12,654 (19%)

3,429 (13%)

9,225 (23%)

<0.0001

Vasopressors

40,126 (59%)

14,211 (52%)

25,915 (64%)

<0.0001

ICU mortality

22,970 (34%)

6,613 (24%)

16,357 (41%)

<0.0001

In-hospital mortality

22,447 (33%)

6,088 (22%)

16,359 (41%)

<0.0001

  1. Characteristics of patients from the College des Utilisateurs de Bases de données en Réanimation (Cub-Rea) database with severe sepsis and septic shock, and distribution according to their eligibility or non-eligibility to randomized controlled trials (RCTs). Results expressed as number (%) and median (interquartile range). P <0.05 was statistically significant. ED, emergency department; SAPS, Simplified Acute Physiological Score.