| |
Total population (n= 67,717)
|
Eligible for RCT (n= 27,392)
|
Non-eligible for RCT (n= 40,325)
|
P value
|
|---|
|
Age, years
|
64 (50 to 75)
|
58.2 (46 to 68)
|
69 (53 to 79)
|
<0.0001
|
|
Gender, male
|
42,977 (63%)
|
18,177 (66%)
|
24,800 (62%)
|
<0.0001
|
|
Charlson Index ≥2
|
8,366 (12%)
|
1,254 (5%)
|
7,112 (18%)
|
<0.0001
|
|
Referred from ED
|
28,847 (42%)
|
12,730 (46%)
|
16,117 (40%)
|
<0.0001
|
|
SAPS 2
|
46 (34 to 63)
|
38 (25 to 53)
|
49 (36 to 66)
|
<0.0001
|
|
Mechanical ventilation
|
52,783 (78%)
|
21,290 (78%)
|
31,493 (78%)
|
0.249
|
|
Renal replacement therapy
|
12,654 (19%)
|
3,429 (13%)
|
9,225 (23%)
|
<0.0001
|
|
Vasopressors
|
40,126 (59%)
|
14,211 (52%)
|
25,915 (64%)
|
<0.0001
|
|
ICU mortality
|
22,970 (34%)
|
6,613 (24%)
|
16,357 (41%)
|
<0.0001
|
|
In-hospital mortality
|
22,447 (33%)
|
6,088 (22%)
|
16,359 (41%)
|
<0.0001
|
- Characteristics of patients from the College des Utilisateurs de Bases de données en Réanimation (Cub-Rea) database with severe sepsis and septic shock, and distribution according to their eligibility or non-eligibility to randomized controlled trials (RCTs). Results expressed as number (%) and median (interquartile range). P <0.05 was statistically significant. ED, emergency department; SAPS, Simplified Acute Physiological Score.
