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Table 3 Characteristics and eligibility/non-eligibility distribution of severe sepsis and septic shock patients from Cub-Rea

From: Are clinical trials dealing with severe infection fitting routine practices? Insights from a large registry

  Total population (n= 67,717) Eligible for RCT (n= 27,392) Non-eligible for RCT (n= 40,325) P value
Age, years 64 (50 to 75) 58.2 (46 to 68) 69 (53 to 79) <0.0001
Gender, male 42,977 (63%) 18,177 (66%) 24,800 (62%) <0.0001
Charlson Index ≥2 8,366 (12%) 1,254 (5%) 7,112 (18%) <0.0001
Referred from ED 28,847 (42%) 12,730 (46%) 16,117 (40%) <0.0001
SAPS 2 46 (34 to 63) 38 (25 to 53) 49 (36 to 66) <0.0001
Mechanical ventilation 52,783 (78%) 21,290 (78%) 31,493 (78%) 0.249
Renal replacement therapy 12,654 (19%) 3,429 (13%) 9,225 (23%) <0.0001
Vasopressors 40,126 (59%) 14,211 (52%) 25,915 (64%) <0.0001
ICU mortality 22,970 (34%) 6,613 (24%) 16,357 (41%) <0.0001
In-hospital mortality 22,447 (33%) 6,088 (22%) 16,359 (41%) <0.0001
  1. Characteristics of patients from the College des Utilisateurs de Bases de données en Réanimation (Cub-Rea) database with severe sepsis and septic shock, and distribution according to their eligibility or non-eligibility to randomized controlled trials (RCTs). Results expressed as number (%) and median (interquartile range). P <0.05 was statistically significant. ED, emergency department; SAPS, Simplified Acute Physiological Score.