Table 2 Diversity of proposed platelet-associated molecules with known immune functions
From: Bench-to-bedside review: Platelets and active immune functions - new clues for immunopathology?
Molecule | Classification | Functions | Cellular targets | Reference |
|---|---|---|---|---|
ADAM10 (CDw156c) | Enzyme - protease | Shedding of surface receptors in platelets | Platelet, B-cells, malignant cell types, endothelial cells | PMID:20644114 |
ADAM17 (CD156b) | Enzyme - protease | Shedding of surface receptors in platelets | Platelets | PMID:20644114 |
ADAMTS13 | Enzyme - protease | (Sub)endothelial VWF cleavage | Platelets, endothelial cells | PMID:19389207 |
Angiogenin | Enzyme - RNAse | Angiogenesis | Endothelial cells | PMID:18279456 |
Angiopoietin-1 | Growth factor | Angiopoiesis | Endothelial cells | PMID:22071944 |
Angiopoietin-related growth factor | Growth factor | Angiopoiesis | Endothelial cells | PMID:22071944 |
Angiostatin | Enzyme - protease | Angiogenesis | Endothelial cells | PMID:22512504 |
Basigin | Enzyme - protease | Spermatogenesis (P. falciparum binding) | Epithelial cells, endothelial cells, leukocytes, erythrocytes | PMID:21320284 |
BDNF | Growth factor | Neurogenesis | Neurons | PMID:15585351 |
Beta-thromboglobulin | Chemokine | Chemotaxis | Fibroblasts, neutrophils | PMID:11138777 |
bFGF | Growth factors | Angiogenesis | Fibroblasts, endothelial cells | PMID:21142700 |
BMP2 | Cytokine | Osteogenesis | Osteoblast | PMID:22808271 |
BMP6 | Cytokine | Osteogenesis | Mesenchymal stem cells | PMID:19413738 |
CCL17 | Chemokine | Chemotaxis | T cells | PMID:18723831 |
CCL3 (also known as PF4) | Chemokine | Chemotaxis and angiogenesis | Monocytes, neutrophils | PMID:12851650 |
CCL4 | Chemokine | Chemotaxis | Natural killer cells, monocytes, leukocytes | PMID:12851650 |
CCL5 | Chemokine | Chemotaxis | T cells, eosinophils, basophils, leukocytes | PMID:12851650 |
CCL7 | Chemokine | Chemotaxis | Monocytes, macrophages | PMID:12851650 |
CRP | Inflammatory marker | Modulator of innate and adaptive immunity | Endothelial cells, platelets, polymorpho-nuclear leukocytes, monocytes | PMID:15492312 |
CTGF | Growth factor | Angiogenesis | Endothelial cells, fibroblasts, monocytes, chondrocyte | PMID:15598883 |
CXCL4 | Chemokine | Angiogenesis | Neutrophils, monocytes, endothelial cells, fibroblasts | PMID:1718005 |
CXCL5 | Chemokine | Chemotaxis | Neutrophils, epithelial cells | PMID:12851650 |
CXCL7 | Chemokine | Chemotaxis | Fibroblasts, neutrophils, monocytes | PMID:18723831 |
EGF | Growth factor | Chemotaxis | Epidermal cells, epithelial cells, fibroblasts | PMID:1572403 |
Endostatin | Cytokine | Mitogen | Endothelial cells | PMID:21680800 |
Endothelial cell-selective adhesion molecule | Immunoglobulin superfamily | Angiogenesis | Neutrophils, monocytes, endothelial cells | PMID:17723134 |
Gas-6 | Growth factor | Angiogenesis | Vascular smooth muscle cells, endothelial cells | PMID:10648841 |
HMGB1 | Cytokine | Angiogenesis | Neutrophil, monocytes, dendritic cells, macrophages | PMID:11154118 |
IGFBP3 | Growth factor | Modulator of innate and adaptive immunity | Fibroblasts | PMID:7679986 |
IL-1-α | Cytokine | Modulator of innate and adaptive immunity and angiogenesis | Endothelial cells, dendritic cells, monocytes, macrophages, B and T cells | PMID:7631154 |
IL-1-β | Cytokine | Modulator of innate and adaptive immunity and angiogenesis | Endothelial cells, dendritic cells, monocytes, macrophages, B and T cells | PMID:7631154 |
IL-7 | Cytokine | Modulator of innate and adaptive immunity | T and B cells, natural killer cells, macrophages, monocytes | PMID:12742982 |
IL-8 | Chemokine | Modulator of innate and adaptive immunity | Neutrophils, B cells, endothelial cells, macrophage | PMID:14713510 |
Osteoprotegerin | Cytokine | Modulator of innate and adaptive immunity | Osteoclasts | PMID:14585373 |
PAI-1 | Enzyme - protease | Chemotaxis | Lymphocytes, neutrophils | PMID:17884148 |
PDGF | Growth factor | Osteogenesis | Epithelial cells, endothelial cells, smooth muscle cells, fibroblasts, chondrocytes | PMID:2835772 |
Soluble CD40 ligand | Cytokine | Angiogenesis and chemotaxis | Endothelial cells | PMID:12186789 |
Soluble CD62P | Cytokine | Angiogenesis and chemotaxis | B cells, dendritic cells, platelets | PMID:9496730 |
TGF-β | Growth factor | Modulator of innate and adaptive immunity | Neutrophils, monocytes | PMID:11012227 |
Thrombocidin-1 | Chemokine, antimicrobial factor | Cellular interaction | Epithelial cells, endothelial cells, B cells | PMID:10877842 |
Thrombocidin-2 | Chemokine, antimicrobial factor | Modulator of innate and adaptive immunity | Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Lactococcus lactis, fungicidal for Cryptococcus neoformans | PMID:10877842 |
Thrombospondin-1 | Cytokine | Modulator of innate and adaptive immunity | Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Lactococcus lactis, fungicidal for Cryptococcus neoformans | PMID:16263699 |
Tissue inhibitor of metalloproteinases-1 | Enzyme - protease | Modulator of innate immunity | Endothelial cells, neutrophils, vascular smooth muscle cells, fibroblasts | PMID:19410025 |
Tissue inhibitor of metalloproteinases-2 | Enzyme - protease | Inflammation | Keratinocytes, endothelial cells | PMID:19410025 |
Tissue inhibitor of metalloproteinases-3 | Enzyme - protease | Angiogenesis | Keratinocytes, endothelial cells | PMID:19410025 |
Tissue inhibitor of metalloproteinases-4 | Enzyme - protease | Angiogenesis | Keratinocytes, endothelial cells | PMID:19410025 |
VEGF | Growth factor | Angiogenesis | Endothelial cells | PMID:21680800 |