Skip to main content
Figure 2 | Critical Care

Figure 2

From: Blockade ofthe negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis

Figure 2

Anti-PD-1, anti-PD-L1 and anti-CTLA-4 improve survival in single-hit fungal sepsis. Mice were injected via tail vein with 50 μl of the 0.5A600Candida suspension.(A) Anti-PD-1 or anti-PD-L1 antibody was injected i.p. on days 2, 5 and 8 post-Candida injection.Fluconazole was administered by i.p. injection daily on days 5 to 10.Mice treated with anti-PD-1 or anti-PD-L1 had significantly improved survival compared to controls (P <0.01).Data represent the combined results of three separate studies.(B) Anti-CTLA-4 was administered i.p on days 4, 7 and 10 post-Candida.Fluconazole was administered by i.p. injection daily on days 10 and 11.Mice treated with anti-CTLA-4 had improved survival versus controls (P <0.05).Data represent combined results of two studies. CTLA-4, cytotoxic T-lymphocyte antigen-4; PD-1, programmed cell death 1; PD-L1, programmed cell death ligand 1.

Back to article page

Critical Care

ISSN: 1364-8535