Table 1 Patient characteristics and comparison between patients who did and did not achieve the PK/PD target of 100% f T>MIC and 50% f T>MIC. Data are reported as median (interquartile range).
Variable | All patients (n = 60) | PK/PD target (100% f T>MIC) achieved (n = 33/60) (55%) | PK/PD target (100% f T>MIC) not achieved (n =27/60) (45%) | P value | PK/PD Target (50% f T>MIC) achieved (n = 43/52) (86%) | PK/PD target (50% f T>MIC) not achieved (n=7/52) (14%) | P value |
|---|---|---|---|---|---|---|---|
Male gender (n, %) | 51 (85%) | 28 (84%) | 23 (85%) | 0.721 | 36 (84 %) | 7 (100%) | 0.330 |
Age (years) | 56 (48-67) | 61 (53-73) | 51(30-60) | 0.016 | 60 (52-72) | 48 (25-67) | 0.054 |
Weight (kg) | 78 (69-90) | 75 (65-81) | 83 (75-90) | 0.014 | 75 (66-85) | 85 (75-90) | 0.041 |
Height (m) | 1.75 (1.70-1.80) | 1.75 (1.67-1.79) | 179 (1.72-1.80) | 0.170 | 1.74 (1.68-1.80) | 1.79 (1.75-1.80) | 0.098 |
BMI | 25 (22-28) | 24 (22-27) | 25 (24-29) | 0.084 | 24 (22-27) | 25 (25-28) | 0.188 |
SOFA at the day of study | 5 (3-7) | 5 (2-8) | 5 (3-6) | 0.693 | 5 (3-8) | 4 (2-6) | 0.358 |
Serum creatinine concentration (μmol/L) | 54 (43-75) | 53 (44-79) | 56 (41 - 64) | 0.623 | 57 (44-76) | 54 (38-59) | 0.306 |
Creatinine clearance (mL/min) | 104 (87-123) | 165 (138-208) | <0.001 | 106 (91-143) | 215 (190-246) | <0.001 | |
Antibiotic used Meropenem (n, %) Piperacillin (n, %) | 17 (30%) 43 (70%) | 7/17 (41%) 25/43 (58%) | 10/17 (59%) 18/43 (42%) | 0.24 | 9/11 (82 %) 33/41 (80 %) | 2/11 (18 %) 8/41 (20 %) | 0.515 |