Figure 3From: Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumoniaIκBα modulated structural lung injury induced by acute pneumonia. Overexpression of IκBα attenuated the decrement in alveolar airspace and the increase in alveolar tissue (A) after pneumonia-induced lung injury. (B) Image from a pneumonia-injured lung that received intratracheal vehicle, demonstrating increased wall thickness and inflammatory cell infiltrate. (C through E) Images from pneumonia-injured lungs that received increasing doses of intratracheal vector encoding the IκBα transgene. The animals that received the intermediate (5 × 1010) dose demonstrated reduced injury and inflammatory cell infiltration. Vehicle, animals that received intratracheal vehicle alone; IκBα 5 × 109, animals that received 5 × 109 AAV6 particles encoding IκBα; IκBα 1 × 1010, animals that received 1 × 1010 AAV6 particles encoding IκBα; IκBα 5 × 1010, animals that received 5 × 1010 AAV6 particles encoding IκBα. Significantly different from vehicle group (P < 0.05, ANOVA). S cale bar, 200 μm.Back to article page