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Table

From: An investigation of the offset of pharmacodynamic effects of remifentanil following prolonged infusion in ICU patients with varying degrees of renal dysfunction: preliminary results

  Renal status: Renal status:
  normal/mild PD moderate/severe PD
Time of down offset (min) offset (min)
titration (h) (mean, SD) (mean, SD)
8 15.6 ± 7.4 (n = 10) 19 ± 15.7 (n = 27)
24 13.8 ± 7.7 (n = 10) 20.3 ± 11.7 (n = 20)
48 16.1 ± 7.2 (n = 8) 15.4 ± 7.4 (n = 12)
72 14.8 ± 5.7 (n = 6) 25.3 ± 12.6 (n = 11)