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Table 2 Performance of studied variables in predicting mortality

From: Impact of interleukin-10, soluble CD25 and interferon-γ on the prognosis and early diagnosis of bacteremic systemic inflammatory response syndrome: a prospective observational study

Variable Parameter D-1 values (95% CI) D-7 values (95% CI)
IL-10 AUROCC 0.942 (0.81, 0.99) 0.971 (0.850, 0.99)
  AUROCC significance P = 0.0001 P = 0.0001
  Cutoff 3.05 3.40
  Sensitivity 91.67 (61.5, 99.8) 100.00 (73.5, 100.0)
  Specificity 86.96 (66.4, 97.2) 95.65 (78.1, 99.9)
  Positive likelihood ratio 7.03 (2.4, 20.5) 23.00 (3.4, 156.4)
  Negative likelihood ratio 0.096 (0.01, 0.6) 0.00
sCD25 AUROCC 0.793 (0.62, 0.91) 0.861 (0.70, 0.95)
  AUROCC significance P = 0.0047 P = 0.0001
  Cutoff 19.9 20.4
  Sensitivity 83.33 (51.6, 97.9) 91.67 (61.5, 99.8)
  Specificity 91.30 (72.0, 98.9) 91.30 (72.0, 98.9)
  Positive likelihood ratio 9.58 (2.5, 36.9) 10.54 (2.8, 40.1)
  Negative likelihood ratio 0.18 (0.05-0.7) 0.091 (0.01-0.6)
IFN-γ AUROCC 0.594 (0.415, 0.756) 0.815 (0.648, 0.926)
  AUROCC significance P = 0.4447 P = 0.0011
  Cut-off 9.00 5.79
  Sensitivity 50.00 (21.1, 78.9) 66.67 (34.9, 90.1)
  Specificity 86.96 (66.4, 97.2) 95.65 (78.1, 99.9)
  Positive likelihood ratio 3.83 (1.2, 12.7) 15.33 (2.2, 108.7)
  Negative likelihood ratio 0.58 (0.3, 1.0) 0.35 (0.2, 0.8)
PCT AUROCC 0.768 (0.595, 0.893) 0.904 (0.756, 0.977)
  AUROCC significance P = 0.0027 P = 0.0001
  Cutoff 0.35 0.87
  Sensitivity 83.33 (51.6, 97.9) 75.00(42.8, 94.5)
  Specificity 69.57 (47.1, 86.8) 95.65 (78.1, 99.9)
  Positive likelihood ratio 2.74 (1.4, 5.3) 17.25 (2.5, 120.6)
  Negative likelihood ratio 0.24 (0.07, 0.9) 0.26 (0.10, 0.7)
SOFA AUROCC 0.870 (0.713, 0.959) 0.944 (0.810, 0.993)
  AUROCC significance P = 0.0001 P = 0.0001
  Cutoff 6 7
  Sensitivity 83.33(51.6, 97.9) 100.00 (73.5, 100.0)
  Specificity 86.96 (66.4, 97.2) 86.96 (66.4, 97.2)
  Positive likelihood ratio 6.39 (2.2, 18.9) 7.67 (2.7, 22.0)
  Negative likelihood ratio 0.19 (0.05, 0.7) 0.00
  1. Prognostic accuracy of IL-10, sCD25, IFN-γ, procalcitonin (PCT) and Sequential Organ Failure Assessment (SOFA) score evaluated by receiver-operating characteristic (ROC) analysis carried out on samples obtained at the time of hospital presentation (D-1) and at the end of first week of the hospital stay (D-7), to estimate the pro- and anti-inflammatory mediators as prognostic markers of poor outcome in critically ill patients. AUROCC, area under the ROC curv