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Table 2 Performance of studied variables in predicting mortality

From: Impact of interleukin-10, soluble CD25 and interferon-γ on the prognosis and early diagnosis of bacteremic systemic inflammatory response syndrome: a prospective observational study

Variable

Parameter

D-1 values (95% CI)

D-7 values (95% CI)

IL-10

AUROCC

0.942 (0.81, 0.99)

0.971 (0.850, 0.99)

 

AUROCC significance

P = 0.0001

P = 0.0001

 

Cutoff

3.05

3.40

 

Sensitivity

91.67 (61.5, 99.8)

100.00 (73.5, 100.0)

 

Specificity

86.96 (66.4, 97.2)

95.65 (78.1, 99.9)

 

Positive likelihood ratio

7.03 (2.4, 20.5)

23.00 (3.4, 156.4)

 

Negative likelihood ratio

0.096 (0.01, 0.6)

0.00

sCD25

AUROCC

0.793 (0.62, 0.91)

0.861 (0.70, 0.95)

 

AUROCC significance

P = 0.0047

P = 0.0001

 

Cutoff

19.9

20.4

 

Sensitivity

83.33 (51.6, 97.9)

91.67 (61.5, 99.8)

 

Specificity

91.30 (72.0, 98.9)

91.30 (72.0, 98.9)

 

Positive likelihood ratio

9.58 (2.5, 36.9)

10.54 (2.8, 40.1)

 

Negative likelihood ratio

0.18 (0.05-0.7)

0.091 (0.01-0.6)

IFN-γ

AUROCC

0.594 (0.415, 0.756)

0.815 (0.648, 0.926)

 

AUROCC significance

P = 0.4447

P = 0.0011

 

Cut-off

9.00

5.79

 

Sensitivity

50.00 (21.1, 78.9)

66.67 (34.9, 90.1)

 

Specificity

86.96 (66.4, 97.2)

95.65 (78.1, 99.9)

 

Positive likelihood ratio

3.83 (1.2, 12.7)

15.33 (2.2, 108.7)

 

Negative likelihood ratio

0.58 (0.3, 1.0)

0.35 (0.2, 0.8)

PCT

AUROCC

0.768 (0.595, 0.893)

0.904 (0.756, 0.977)

 

AUROCC significance

P = 0.0027

P = 0.0001

 

Cutoff

0.35

0.87

 

Sensitivity

83.33 (51.6, 97.9)

75.00(42.8, 94.5)

 

Specificity

69.57 (47.1, 86.8)

95.65 (78.1, 99.9)

 

Positive likelihood ratio

2.74 (1.4, 5.3)

17.25 (2.5, 120.6)

 

Negative likelihood ratio

0.24 (0.07, 0.9)

0.26 (0.10, 0.7)

SOFA

AUROCC

0.870 (0.713, 0.959)

0.944 (0.810, 0.993)

 

AUROCC significance

P = 0.0001

P = 0.0001

 

Cutoff

6

7

 

Sensitivity

83.33(51.6, 97.9)

100.00 (73.5, 100.0)

 

Specificity

86.96 (66.4, 97.2)

86.96 (66.4, 97.2)

 

Positive likelihood ratio

6.39 (2.2, 18.9)

7.67 (2.7, 22.0)

 

Negative likelihood ratio

0.19 (0.05, 0.7)

0.00

  1. Prognostic accuracy of IL-10, sCD25, IFN-γ, procalcitonin (PCT) and Sequential Organ Failure Assessment (SOFA) score evaluated by receiver-operating characteristic (ROC) analysis carried out on samples obtained at the time of hospital presentation (D-1) and at the end of first week of the hospital stay (D-7), to estimate the pro- and anti-inflammatory mediators as prognostic markers of poor outcome in critically ill patients. AUROCC, area under the ROC curv
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Critical Care

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